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| 紫杉醇联合顺铂治疗晚期食管癌20例临床研究 | |
| 引用本文： | 泮卫红,罗青峰,陈惠馨,范鹏. 紫杉醇联合顺铂治疗晚期食管癌20例临床研究[J]. 中国医药导报, 2010, 7(26): 130-131 |
| 作者姓名： | 泮卫红 罗青峰 陈惠馨 范鹏 |
| 作者单位： | 山东省淄博市万杰肿瘤医院肿瘤1科,山东淄博,255213 |
| 摘 要： | 目的：探讨紫杉醇联合顺铂治疗晚期食管癌的临床疗效以及不良反应发生情况。方法：2009年1～9月我科收治晚期食管癌患者20例,均行紫杉醇联合顺铂化疗,观察治疗效果。结果：全部患者经2个周期的化疗后,CR3例,PR13例,SD6例,PD6例,有效率为55%,随访1～3年。缓解时间为3.5～8.0个月,生存期为3～24个月。主要不良反应为白细胞减少发生率为55%,胃肠道反应（恶心、呕吐等）发生率为45%。结论：紫杉醇联合顺铂治疗晚期食管癌近期疗效较好,不良反应较轻,值得应用。 |
| 关 键 词： | 紫杉醇 顺铂 食管癌 |
Clinical research of 20 cases of advanced esophageal cancer treated with Paclitaxel and Cisplatin |
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| PAN Weihong,LUO Qingfeng,CHEN Huiqing,FAN Peng. Clinical research of 20 cases of advanced esophageal cancer treated with Paclitaxel and Cisplatin[J]. China Medical Herald, 2010, 7(26): 130-131 | |
| Authors: | PAN Weihong LUO Qingfeng CHEN Huiqing FAN Peng |
| Affiliation: | (The First Department of Oncology of Wanjie Cancer Hospital,Zibo City,Shandong Province,Zibo 255213,China) |
| Abstract: | Objective：To evaluate the clinical efficacy and adverse events of advanced esophageal cancer treated with Paclitaxel and Cisplatin.Methods：From January to September 2009,28 patients with advanced esophageal cancer treated in our department,underwent Paclitaxel and Cisplatin chemotherapy,the clinical efficacy was observed.Results：After 2 cycles of chemotherapy,CR 3 cases,PR 13 cases,SD 6 cases,PD cases,the effective rate（CR＋PR） was 55%,followed up 1 to 3 years.Remission time was 3.5-8.0 months,survival ranged from 3 to 24 months.The main side effects,the leukopenia rate was 55%,the gastrointestinal reactions（nausea,vomiting,etc.） rate was 45%.Conclusion：Paclitaxel and Cisplatin for advanced esophageal cancer has better effect,less adverse reactions,should be applied. |
| Keywords: | Paclitaxel Cisplatin Esophageal cancer |
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