左旋咪唑等5种药物阻断黄曲霉毒素B1致大鼠肝癌作用的实验研究

本文报告用动物体内短期实验模型,研究左旅咪唑、番石榴叶、绞股兰、维酶素及葫芦素等5种药物影响黄曲霉毒素B_1(AFB_1)致大鼠肝癌的作用。结果发现左旋咪唑对AFB_1诱发大鼠肝组织γ-GT酶变灶平面和立体的5个指标,均显著低于对照组(P<0.05～0.001),表明左旋咪唑对AFB_1致肝癌具有很强的抑制作用;番石榴叶也有较强的抑制效果;绞股兰和维酶素则无显著影响;葫芦素对AFB_1诱发肝γ-GT酶变灶的形成有促进作用。实验结果提示,左旋咪唑对人类肝癌的化学预防将具有较大的实用价值。

A STUDY OF THE BLOCKING EFFECTS OF FIVE DRUGS ON HEPATOCARCINOGENESIS INDUCED BY AFLATOXIN B_1 (AFB_1) IN RATS

Five drugs, levamisoli (LMS), leaf of guava (LG), jiaogulan(JGL), weimeisu (WMS) and hulusu (HLS), were tested for the blocking effectson AFB_1 -induced hepatocarcinogenesis by using the short term in vivoexperimental model in rats. Five plane and stereo figures of the gammaglutamyltranspeptidase positive hepatocyticfoci (GGT foci) were measured andcalculated with the computerized image analysis system. The results showedthat the number and size of the GGT fooi in the LMS group were significantly lesser and smaller than those of the control group. The GGT foci of the LGgroup showed somewhat lesser and significantly smaller than that of thecontrols. JGL and WMS showed no significant influence on AFB_1-inducedhepatocarcinogenesis, while HLS has a promotive effect in rats. These resultssuggest that LMS posseses remarkable blocking effects on AFB_1 -carcinogenesis,and is of practical value in the field study of chemoprevention of the humanliver cancer.