Molecular cloning and expression of an anti-idiotype antibody mimicking a protective oligosaccharide of the parasite Schistosoma mansoni |
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| Authors: | Karine Petitprez Jean-Marie Grzych Christine Pierrot Claude Godin André Capron Jamal Khalife |
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| Institution: | (1) INSERM U167 Centre d'Immunologie et de Biologie Parasitaire, Institut Pasteur, F-59019 Lille, France Tel.: (33) 20.87.78.09; Fax: (33) 20.87.78.88; e-mail: karine.petitprez@pasteur-lille.fr, FR |
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| Abstract: | Genes encoding the heavy and light chains of an anti-idiotype antibody (AB2) mimicking a protective oligosaccharide of Schistosoma mansoni were cloned and expressed as a single-chain Fv fragment. The expression in a functional state was tested using the AB1. A
specific binding between sFv and AB1 was observed. Immunization with the recombinant AB2 indicates its capacity to elicit
anti-S. mansoni antibodies.
Received: 28 April 1997 / Accepted: 24 June 1997 |
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