| 腹腔镜手术全身麻醉中联合应用瑞芬太尼与七氟烷药效学相互作用的研究 |
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| 引用本文： | 杨璐,毕姗姗,卢炜,杨拔贤. 腹腔镜手术全身麻醉中联合应用瑞芬太尼与七氟烷药效学相互作用的研究[J]. 中国微创外科杂志, 2008, 8(4): 345-348 |
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| 作者姓名： | 杨璐 毕姗姗 卢炜 杨拔贤 |
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| 作者单位： | 1. 北京大学人民医院麻醉科,北京,100034
2. 北京大学药学院,北京,100083 |
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| 摘 要： | 目的探讨腹腔镜手术全身麻醉中瑞芬太尼与七氟烷的药效学相互作用。方法ASAⅠ级妇科或外科拟行择期腹腔镜手术的患者65例,每名患者预先选定七氟烷的目标浓度,并在试验过程中维持七氟烷呼出浓度恒定。采用七氟烷吸入诱导。当呼气末七氟烷浓度达到设定浓度,观察七氟烷与瑞芬太尼不同剂量组合(0、1、2、4、6和8ng/ml)时,患者对100Hz、60mA、5s的强直电刺激(electrical tetanus stimuli,ETS)的体动和循环反应。应用NONMEM软件对原始数据进行分析和浓度-效应曲线(即S形曲线)的拟合。Logistic回归模型求算七氟烷强直电刺激时的肺泡最低有效浓度(minimal alveolar concentration,MAC)。结果单独应用七氟烷,抑制ETS引起体动反应的MACETS为1.52%,抑制ETS引起循环反应的MACETS为2.24%。小剂量的瑞芬太尼即可明显降低七氟烷的MACETS。当瑞芬太尼的靶控浓度为8ng/ml时,抑制强直电刺激体动反应和循环反应的MACETS值分别下降70.0%和76.3%。结论瑞芬太尼与七氟烷在抑制强直电刺激的体动和循环反应方面存在协同作用。瑞芬太尼可以...
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| 关 键 词： | 瑞芬太尼 七氟烷 药物相互作用 电刺激 |
| 文章编号： | 1009-6604(2008)04-0345-04 |
| 修稿时间： | 2007-12-28 |
Pharmacodynamic Interactions between Remifentanil and Sevoflurane during General Anesthesia for Laparoscopic Operations |
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| Affiliation: | Yang Lu; Bi Shanshan; Lu Wei; et al.Department of Anesthesiology; Peking University People s Hospital; Beijing 100034; China; |
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| Abstract: | Objective To investigate the pharmacodynamic interactions between remifentanil and sevoflurane during general anesthesia for laparoscopic operation.Methods Sixty-five ASA I patients undergoing selective laparoscopic operations at the Department of Gynecology and the Department of General Surgery in People s Hospital were enrolled in this study.Sevoflurane was used for anesthesia induction with its expired concentration being kept stable,and different dosages of remifentanil(0,1,2,4,6,and 8 ng/ml)being added... |
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| Keywords: | Remifentanil Sevoflurane Drug-drug interaction Electrical stimuli |
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