~(131)I不同剂量法治疗甲亢疗效对比

目的 比较131I固定剂量法和计算剂量法治疗甲亢的近期疗效。方法 148例甲亢患者随机分配为固定剂量组和计算剂量组,131I治疗后6个月随访,检测患者血清促甲状腺激素(TSH)、游离三碘甲腺原氨酸(FT₃)和游离甲状腺素(FT₄)水平,评价131I治疗效果。结果 131I治疗后6个月固定剂量组、计算剂量组甲减发生率分别为31.1%、28.4%,统计学差异无意义(χ2=0.742,P=0.528),总治愈率分别为93.3%、85.2%,统计学差异无意义(χ2=0.958,P=0.403)。不同治疗结果(甲亢、甲状腺功能正常和甲减)之间甲状腺质量的统计学差异有意义(F=13.639,P=0.000),患者年龄、24h甲状腺吸碘率(RAIU)统计学差异无意义(F=1.374,P=0.241;F=2.534,P=0.137)。结论 131I固定剂量法简化治疗步骤,节约治疗费用,是值得提倡的治疗方法。

A randomized study of different radioiodine doses treatment hyperthyroidism

Objective To compare clinical efficacy of ~(131)I treatment for hyperthyroidism between fixed dose and calculated dose methods.Methods One hundred and forty eight patients with hyperthyroidism were randomly allocated fixed dose and calculated dose groups.Follow up was done 6months post therapy,serum free triiodothyronine(FT_3),free thyroxin(FT_4)and thyroid stimulating hormone(TSH)were measured and following clinical outcome was monitored.Results The occurrence of hypothyroidism 6 months after ~(131)I treatment in fixed dose and calcuhted dose groups was 31.1% and 28.4%respectively.There was no distinct difference between them(χ~2=0.742,P=0.528).The cure rate was 93.3%and 85.2% respectively.There was no distinct difference between them(χ~2=0.958,P=0.403).A good correlation was between clinical efficacy and thyroid mass(F=13.639,P=0.000).There was no distinct difference between the two groups of ages and 24h radioactive iodine uptake(F=1.374,P=0.241;F=2.534,P=0.137).Conclusion The use of a fixed dose metllod simplifies the approach to treatment with potential cost savings.