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| 米非司酮对人蜕膜与绒毛糖脂及雌孕激素受体的影响 | |
| 引用本文： | 周剑萍 刘银坤. 米非司酮对人蜕膜与绒毛糖脂及雌孕激素受体的影响[J]. 生殖与避孕, 1996, 16(5): 357-360,364 |
| 作者姓名： | 周剑萍 刘银坤 |
| 作者单位： | 上海医科大学妇产科医院，上海医科大学中山医院肝癌研究所 |
| 摘 要： | 本文从糖脂与激素受体等方面观察了米非司酮抗早孕的作用机理。采用Ｌａｄｉｓｃｈ微量分部、ＳｅｐｈａｄｅｘＧ－２５柱层析及高效薄层定量分析（ＨＰＴＬＣ），发现米非司酮引起蜕膜与绒毛糖酯含量及组分的变化；应用ＤＣＣ法测定蜕膜组织中雌、孕激素受体（ＥＲ、ＰＲ）。结果表明米非司酮使蜕膜组织中ＥＲ上升，ＰＲ下降，干扰了ＥＲ与ＰＲ之间的平衡。以上研究提示来非司酮抗早孕作用是多环节的，蜕膜是其重要的作用部位。 |
| 关 键 词： | 米非司酮；糖脂；激素受体；蜕膜；绒毛 |
Effects of Mifepristone on Glycosphingolipids and Estrogen and Progesterone Receptors from Human Decidua and Villi |
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| Zhou Jian-ping, Zhang Jun-hui, Liu Yin-kun,Sun Cui-xiang, Lu Xiang-yun. Effects of Mifepristone on Glycosphingolipids and Estrogen and Progesterone Receptors from Human Decidua and Villi[J]. Reproduction and Contraception, 1996, 16(5): 357-360,364 | |
| Authors: | Zhou Jian-ping Zhang Jun-hui Liu Yin-kun Sun Cui-xiang Lu Xiang-yun |
| Abstract: | Effects of mifepristone on glycosphingolipids and hormone receptors from human decidua and villi were studied to investigate the mechanism of terminating pregnancy. By using the Ladisch partition methods,Sephadex G-25 chromatography and quantitative densitometric technique,alteration of the amount and composition of glycosphingolipids from decidua and villi was found under effects of mifepristone. Increasing estradiol receptors and declining progesterone receptors were measured from mifepristone affected decidua. These evidences indicated that roles of mifepristone against early pregnancy were wide and mainly direct through decidua. |
| Keywords: | Mifepristone Glycosphingolipids Hormone receptor Decidua Villi |
| 本文献已被 CNKI 维普 等数据库收录！ | |