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Depression,neighborhood deprivation and risk of type 2 diabetes
Affiliation:1. Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden;2. Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden;3. Haematology Centre, Karolinska University Hospital, Solna, Stockholm, Sweden;4. Centre for Pharmacoepidemiology, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden;5. Department of Proteomics, School of Biotechnology, KTH, Science for Life Laboratory, Stockholm, Sweden;6. Department of Internal Medicine, Södersjukhuset, Stockholm, Sweden;1. Department of Public Health, Faculty of Medicine, Norwegian University of Science and Technology, 7491 Trondheim, Norway;2. Forensic Department, Research Centre Bröset, St. Olav''s University Hospital Trondheim, Trondheim, Norway;3. HUNT Research Center, Norwegian University of Science and Technology, Levanger, Norway;4. Regional Center for Health Care Improvement, St Olav Hospital, Trondheim, Norway
Abstract:
Neighborhood characteristics have been associated with both depression and diabetes, but to date little attention has been paid to whether the association between depression and diabetes varies across different types of neighborhoods. This prospective study examined the relationship between depression, neighborhood deprivation, and risk of type 2 diabetes among 336,340 adults from a national-representative sample of primary care centers in Sweden (2001–2007). Multi-level logistic regression models were used to assess associations between depression and risk of type 2 diabetes across affluent and deprived neighborhoods. After accounting for demographic, individual-level socioeconomic, and health characteristics, depression was significantly associated with risk of diabetes (odds ratio (OR): 1.10, 95% confidence interval (CI): 1.06–1.14), as was neighborhood deprivation (OR for high vs. low deprivation: 1.66, 95% CI: 1.22–1.34). The interaction term between depression and neighborhood deprivation was non-significant, indicating that the relationship between depression and diabetes risk is similar across levels of neighborhood socioeconomic deprivation.
Keywords:Depression  Type 2 diabetes mellitus  Residence characteristics  Multi-level analysis  Socioeconomic factors
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