Methicillin-resistant Staphylococcus aureus ST30-SCCmec IVc clone as the major cause of community-acquired invasive infections in Argentina |
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| Institution: | 1. German Federal Institute for Risk Assessment (BfR), Department Biological Safety, Berlin, Germany;2. Current affiliation: The Federal Office of Consumer Protection and Food Safety, Berlin, Germany;1. Beijing Advanced Innovation Centre for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, China;2. Shandong Provincial Key Laboratory of Infectious Disease Control and Prevention, Shandong Centre for Disease Control and Prevention, Jinan, Shandong, China;3. Public Health Agency of Sweden, Solna, Sweden;4. Global Health – Health Systems and Policy, Department of Public Health Sciences, Karolinska Institutet, Solna, Sweden;5. Institute of Microbiology and Epizootics, Centre for Infection Medicine, Department of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany;6. Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden;7. Shandong University, Centre for Health Management and Policy, Jinan, Shandong, China;8. NHFPC (Shandong University), Key Laboratory of Health Economics and Policy Research, Jinan, Shandong, China;9. Department of Animal Health and Antimicrobial Strategies, National Veterinary Institute (SVA), Uppsala, Sweden |
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| Abstract: | Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infections have become a major concern worldwide. We conducted a prospective multicenter study of invasive CA-MRSA to evaluate clinical features and genotype of strains causing invasive infections in Argentina. A total of 55 patients with invasive CA-MRSA infections were included. Most patients (60%) had bloodstream infections, 42% required admission to intensive care unit and 16% died. No CA-MRSA isolates were multiresistant (resistant ⩾3 classes of antibiotics). All isolates carried Panton-Valentine leukocidin (PVL) genes and staphylococcal cassette chromosome (SCCmec) type IV. The majority CA-MRSA strains belonged to ST30 and had identical pulsed-field gel electrophoresis (PFGE) patterns, qualifying as a clonal dissemination of a highly transmissible strain. The main clone recovered from patients with CA-MRSA invasive infections was genotyped as pulsed-field gel electrophoresis type C-ST30, SCCmec type IVc-spa type 019, PVL positive. It has become predominant and replaced the previously described CA-MRSA clone (PFGE type A, ST5, SCCmec type IV, spa type 311). |
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| Keywords: | Methicillin-resistance CA-MRSA MRSA invasive infection Molecular epidemiology |
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