|
|||||
|
|
| P38MAPK信号通路与肝纤维化 | |
| 引用本文： | 杨清高,刘绍能. P38MAPK信号通路与肝纤维化[J]. 世界华人消化杂志, 2012, 0(24): 2231-2236 |
| 作者姓名： | 杨清高 刘绍能 |
| 作者单位： | 中国中医科学院广安门医院消化内科 |
| 基金项目： | 国家自然科学基金资助项目,No.81072803~~ |
| 摘 要： | 丝裂原活化蛋白激酶(mitogen activated protein kinase,MAPK)是真核细胞介导细胞外信号到细胞内反应的重要信号传导系统之一,P38MAPK是MAPK家族的重要成员,他在炎症、细胞应激、凋亡、细胞周期和生长等多种生理和病理过程中起重要作用.现从其组织结构、分布亚型、激活途径和功能等方面,对P38MAPK信号通路在肝纤维化(hepatic fibrosis,HF)过程中所起的重要作用作一综述,旨在为相关研究提供参考资料. |
| 关 键 词： | P38MAPK 信号通路 肝纤维化 |
P38 MAPK signaling pathway and hepatic fibrosis |
|
| Qing-Gao Yang, Shao-Neng Liu. P38 MAPK signaling pathway and hepatic fibrosis[J]. World Chinese Journal of Digestology, 2012, 0(24): 2231-2236 | |
| Authors: | Qing-Gao Yang Shao-Neng Liu |
| Affiliation: | , Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China |
| Abstract: | Mitogen-activated protein kinase (MAPK) cascade is one of eukaryotic cell-mediated extracellular signal responses to distinct environmental stresses. P38 MAPK is an important member of the MAPK family and plays an important role in a variety of physiological and pathological processes such as inflammation, cellular stress, apoptosis, cell cycle and growth. This article reviews the role of the P38 MAPK signaling pathway in the pathogenesis of hepatic fibrosis in terms of its structure composition, distribution and subtypes, activation pathways and function. |
| Keywords: | P38 MAPK Signaling pathway Hepatic fibrosis |
| 本文献已被 CNKI 等数据库收录！ | |