培哚普利联合吲达帕胺对原发性高血压的疗效分析

目的：探讨培哚普利联合吲达帕胺对原发性高血压治疗的降压作用与不良反应。方法：选择我科2009年7～12月确诊为原发性高血压的患者90例,随机分为治疗组46例和对照组44例,排除继发性高血压患者,停服原用降压药物5d以上,治疗前后查血、尿常规,心电图和血脂、血糖、肝肾功能,并记录。对照组采用吲达帕胺2.5mg/d或5mg/d降压;治疗组采用吲达帕胺2.5mg/d和培哚普利4mg/d治疗;8周后疗效评定。结果：治疗组总有效率为87.0%,而对照组总有效率为59.1%,组间差异有统计学意义（P〈0.05）,且治疗组不良反应少。结论：培哚普利联合吲达帕胺治疗原发性高血压效果好,且不良反应少,值得临床推广应用。

Efficacy analysis of Perindopril combined with Indapamide in primary hypertension

Objective：To investigate the hypotensive effect and adverse reactions of Perindopril combined with Indapamide in primary hypertension.Methods：From July 2009 to December 2009 in our department,90 patients diagnosed with essential hypertension were randomized groups,46 cases of treatment group and 44 cases of control group,they were excluded secondary hypertension.These patients stopped taking antihypertensive drugs more than 5 days.Before and after treatment,the blood and urine routine,ECG and blood lipids,blood glucose,liver and kidney function were recorded.The control group treated with Indapamide 2.5 mg/d or 5 mg/d;the treatment group treated with Indapamide 2.5 mg/d and Perindopril 4 mg/d;the curative effect were assessed after 8 weeks.Results：The total effective rate of treatment group was 87.0%,and the control group was 59.1%,the difference was statistically significant（P〈0.05）,and the treatment group had less adverse reactions.Conclusion：Perindopril combined with Indapamide in the treatment of primary hypertension has good effect and less adverse reactions,it is worth popularizing.