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Ultrastructural changes induced by hyperthermia in Chinese hamster V79 fibroblasts
Abstract:The effects of hyperthermic treatment on some intracellular components and on the general morphology of Chinese hamster V79 fibroblasts have been studied. After 1 h of heating at 42°C cells show small interruptions of the plasma membrane, dilation of the mitochondrial cristae and dissociation of the polyribosomes. These modifications become progressively more pronounced after 1 or 3 h treatment at 43°C. Severe alterations in the general morphology of the cells are evident after 1 h heating at 45°C.
Keywords:hyperthermia  electron microscopy  cell membranes  mitochondria  ribosomes.
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