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| 洛美沙星注射液与注射用阿昔洛韦配伍稳定性考察 | |
| 引用本文： | 陈春玲,朱华,贾玲昌,尚振海,缪应祥.洛美沙星注射液与注射用阿昔洛韦配伍稳定性考察[J].实用药物与临床,2006,9(3):134-135. |
| 作者姓名： | 陈春玲 朱华 贾玲昌 尚振海 缪应祥 |
| 作者单位： | 1. 江苏省苏北人民医院,扬州,225001 2. 江苏大学药学系,镇江,212001 3. 徐州医学院临床药学系,徐州,221002 |
| 摘 要： | 目的考察门冬氨酸洛美沙星注射液与注射用阿昔洛韦在5%葡萄糖注射液(GS)中配伍的稳定性。方法在25、37℃下,模拟临床常用浓度,将洛美沙星注射液与注射用阿昔洛韦在5%GS中配伍,观察6 h内的配伍液外观、扫描紫外光谱、pH值、洛美沙星及阿昔洛韦含量的变化。结果门冬氨酸洛美沙星注射液在配伍前后pH值有明显变化,注射用阿昔洛韦的pH值变化不明显;25℃时,注射用阿昔洛韦的含量均>90%,37℃时含量均<90%。结论门冬氨酸洛美沙星注射液与注射用阿昔洛韦在5%GS中不宜配伍使用。 |
| 关 键 词： | 门冬氨酸洛美沙星注射液 注射用阿昔洛韦 配伍 稳定性 |
| 文章编号： | 1673-0070（2006）03-0134-02 |
| 收稿时间： | 2005-11-26 |
| 修稿时间： | 2005年11月26 |
Study on compatibility of lomefloxacin aspartate injection with aciclovir injection |
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| CHEN Chun-ling, ZHU Hua, JIA Ling-chang, et al.Study on compatibility of lomefloxacin aspartate injection with aciclovir injection[J].Practical Pharmacy and Clinical Remedies,2006,9(3):134-135. | |
| Authors: | CHEN Chun-ling ZHU Hua JIA Ling-chang |
| Abstract: | Objective To study the stability of lomefloxacin(LFLX) aspartate injection and acyclovir(ACV) for injection in 5% Glucose injection.Methods The mixed solution was laid for 6 hours at 25 ℃ and 37 ℃,then the appearance and pH were observed,and the UV spectrophotometry was developed respectively.Results The pH of LFLX was changed significantly before and after mixing,and the content of ACV was <90% at 37 ℃.Conclusion The preparations can not be used together in 5% glucose injection. |
| Keywords: | Lomefloxacin aspartate injection Aciclovir for injection Compatibility Stability |
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