热休克蛋白70在急性胰腺炎中的作用

热休克蛋白(HSPs)是广泛存在于生物体内的高度保守的一类应激蛋白。HSP对各种刺激具有迅速的反应能力,发挥抗炎、抗氧化、抗细胞凋亡以及分子伴侣等作用,在细胞的生长发育、代谢分化、基因转录、维持组织细胞的自稳和环境适应性方面扮演着重要角色。而其中最受研究者关注的是HSP70,其在生理状态下少量表达,可通过热预处理、药物以及基因转染等方法诱导其产生,从而发挥细胞保护作用。本文就HSP70在急性胰腺炎中的作用以及相关机理的研究进展做一综述。

Research progress of heat shock protein 70 in acute pancreatitis

Heat shock proteins (HSPs) are a highly conserved group of stress proteins which exist in virtually all known organisms. HSPs possess rapid reactive potency to all kinds of stimulus, and have effects on anti-inflamma-tion, anti-oxidation, anti-apoptosis, as well as molecular chaperones. These proteins play an essential role in a variety of cellular activities including cell growth and development, metabolism and differentiation, gene transcription, intracellu-lar homeostasis and environmental adaptability. HSP70 is attracting the most attention among HSPs, which express at a lower degree in physiological condition than induced by prior thermal stress, drug, gene transfection, and consequently exert cytoprotection. Research progresses of HSP70 about its effects and related mechanisms in acute pancreatitis were reviewed in this article.