血清炎症因子在多囊卵巢综合征患者中的表达及其临床意义

目的：探讨血清炎症因子在多囊卵巢综合征(PCOS)患者中的表达特点及其临床意义。方法选取我院妇科2014年10月至2015年10月期间治疗的80例PCOS患者作为观察组，另选取60例正常女性作为对照组，运用酶联免疫吸附法(ELISA)、免疫透射比浊法检测并比较两组受检者的白介素-17(IL-17)、IL-6、C反应蛋白(CRP)、血清促黄体生成素(LH)、总睾酮(TT)以及LH/卵泡生成素(FSH)、胰岛素抵抗指数(HOMA-IR)等水平。结果观察组患者的IL-17、IL-6、CRP、TT水平及LH/FSH、HOMA-IR值分别为(257.87±50.41) pg/mL、(352.04±43.28)μg/mL、(8.01±1.58) mg/L、(2.73±0.79) ng/mL、(2.78±0.50)、(5.62±1.32)，明显高于对照组的（76.87±20.87) pg/mL、（158.57±17.58)μg/mL、(2.26±0.73) mg/L、(0.89±0.42) ng/mL、(1.16±0.49)、(3.64±1.63)，差异均有统计学意义(P<0.05)；观察组中，肥胖患者的IL-17、IL-6、CRP水平及HOMA-IR值分别为(360.87±49.87) pg/mL、(450.56±57.38)μg/mL、(10.28±3.50) mg/L、(6.23±0.33)，均明显高于非肥胖患者的(158.74±50.47) pg/mL、(223.54±20.22)μg/mL、(5.04±1.34) mg/L、(4.02±0.18)，差异均有统计学意义(P<0.05)；对观察组患者的IL-17与其他指标进行Pearson相关性分析，结果显示，IL-17与HOMA-IR、LH/FSH、TT均呈显著正相关(r=0.39、0.41、0.40，P<0.05)。结论 PCOS患者的炎症因子水平显著升高，提示机体可能处于一种慢性亚临床炎症反应状态，且这种炎症反应状态的发生可能与胰岛素抵抗、肥胖等因素有关。

Expression of serum inflammatory factors in the patients with polycystic ovary syndrome and the clinical significance

Objective To explore the expression characteristics and its clinical significance of serum inflamma-tory factors in patients with polycystic ovary syndrome (PCOS). Methods Eighty patients with PCOS treated from Oc-tober 2014 to October 2015 were selected as the study objects (the study group), and another 60 healthy women were se-lected as the control group. Interleukin-17 (IL-17), IL-6, C-reactive protein (CRP), serum luteinizing hormone (LH), to-tal testosterone (TT), LH/follicle-stimulating hormone (FSH), homeostasis model assessment-estimated insulin resistance (HOMA-IR) levels of patients of two groups were detected by using enzyme-linked immunosorbent assay (ELISA), im-mune transmission turbidity method. The detection results were compared and analyzed. Results The levels of IL-17, IL-6, CRP, TT and LH/FSH, HOMA-IR values of the study group were (257.87 ± 50.41) pg/mL, (352.04 ± 43.28)μg/mL, (8.01±1.58) mg/L, (2.73±0.79) ng/mL, (2.78±0.50), (5.62±1.32), which were significantly higher than those of the con-trol group of (76.87±20.87) pg/mL, (158.57±17.58)μg/mL, (2.26±0.73) mg/L, (0.89±0.42) ng/mL, (1.16±0.49), (3.64± 1.63), with statistically significant difference (P<0.05). The levels of IL-17, IL-6, CRP, and HOMA-IR value of the obese patients of the study group were (360.87±49.87) pg/mL, (450.56±57.38)μg/mL, (10.28±3.50) mg/L, (6.23±0.33), which were significantly higher than those of non-obese patients of (158.74 ± 50.47) pg/mL, (223.54 ± 20.22) μg/mL, (5.04 ± 1.34) mg/L, (4.02 ± 0.18), with statistically significant difference (P<0.05). IL-17 and other indicators of patients of the study group were given correlation analysis of Pearson, and the results showed that IL-17 was significantly posi-tively correlated with HOMA-IR, LH/FSH and TT (r=0.39, 0.41, 0.40, P<0.05). Conclusion The level of inflammatory factors of patients with PCOS is significantly higher, which shows that the body may be in a state of chronic subclinical inflammation reaction state, and that the occurrence of this inflammatory reaction state may be related to insulin resis-tance, obesity, and other factors.