Febrile urinary tract infection after pediatric kidney transplantation: a multicenter,prospective observational study |
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| Authors: | Friederike Weigel Anja Lemke Burkhard Tönshoff Lars Pape Henry Fehrenbach Michael Henn Bernd Hoppe Therese Jungraithmayr Martin Konrad Guido Laube Martin Pohl Tomáš Seeman Hagen Staude Markus J. Kemper Ulrike John |
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| Affiliation: | 1.Pediatric Nephrology,University Medical Center Jena,Jena,Germany;2.Pediatric Nephrology,University Childrens Hospital, University Medical Center Hamburg Eppendorf,Hamburg,Germany;3.Department of Pediatrics I,University Children’s Hospital,Heidelberg,Germany;4.Pediatric Nephrology,Hannover Medical School,Hannover,Germany;5.Children’s Hospital Memmingen,Memmingen,Germany;6.Pediatric Nephrology, Children’s Hospital St. Georg,Leipzig,Germany;7.Pediatric Nephrology,University Medical Center Bonn,Bonn,Germany;8.Department of Pediatrics I,University Medical Center Innsbruck,Innsbruck,Austria;9.Pediatric Nephrology,University Medical Center Münster,Münster,Germany;10.Department of Nephrology,University Children’s Hospital,Zurich,Switzerland;11.Pediatric Nephrology,University Children’s Hospital,Freiburg,Germany;12.2nd School of Medicine,University Hospital Motol, Charles University Prague,Prague,Czech Republic;13.Pediatric Nephrology,University Children’s Hospital,Rostock,Germany |
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| Abstract: | BackgroundFebrile urinary tract infections (fUTIs) are common after kidney transplantation (KTx); however, prospective data in a multicenter pediatric cohort are lacking. We designed a prospective registry to record data on fUTI before and after pediatric KTx.MethodsNinety-eight children (58 boys and 40 girls)?≤?18 years from 14 mid-European centers received a kidney transplant and completed a 2-year follow-up.ResultsPosttransplant, 38.7 % of patients had at least one fUTI compared with 21.4 % before KTx ( p?=?0.002). Before KTx, fUTI was more frequent in patients with congenital anomalies of kidneys and urinary tract (CAKUT) vs. patients without (38 % vs. 12 %; p?=?0.005). After KTx, fUTI were equally frequent in both groups (48.7 % vs. 32.2 %; p?=?0.14). First fUTI posttransplant occurred earlier in boys compared with girls: median range 4 vs. 13.5 years ( p?=?0.002). Graft function worsened ( p? ConclusionThis prospective study confirms a high incidence of fUTI after pediatric KTx, which is not restricted to patients with CAKUT; fUTIs have a negative impact on graft function during the infectious episode but not on 2-year graft outcome. |
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