Melanosis coli |
| |
Authors: | Dr E Koskela MD T Kulju MD Y Collan MD |
| |
Institution: | (1) Department of Pathology, University Central Hospital, 70211 Kuopio 21, Finland |
| |
Abstract: | The occurrence of large-bowel melanosis was evaluated by microscopy in 200 large bowels at autopsy. Melanin was seen as yellow-brown
pigment in the macrophages of the lamina propria. The pigment stained with diastase-alcian blue PAS, Fontana, and iron stains.
One hundred nineteen of 200 (59.5 percent) bowels showed melanosis, which was equally common in both sexes. Usually more than
one segment was involved (most commonly, four segments). Melanosis was common in the proximal part of the colon, but much
rarer in distal parts (sigmoid and rectum). Affected segments were successive; negative segments between positive ones were
exceptional. If the rectum was affected, all five proximal segments were affected in 11 of 12 cases. The intensity of melanosis
was directly related to the number of segments involved. In the oral part of the colon, affected males had a higher intensity
of melanosis than affected women, but about the same intensity in the sigmoid and rectum. The fraction of patients with melanosis
increased with age. Of men and women in the age group of 20 to 54 years, 32 and 44 percent were affected, and above the age
of 75 years, 76 and 67 percent, respectively. |
| |
Keywords: | Melanosis Large bowel |
本文献已被 SpringerLink 等数据库收录! |
|