Genetic association between obstructive bronchitis and enzymes of oxidative stress |
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| Authors: | Mario Bauer Carolin Gräbsch Uwe Schlink Norman Klopp Thomas Illig Ursula Krämer Andrea von Berg Beate Schaaf Michael Borte Joachim Heinrich Olf Herbarth Irina Lehmann Stefan Röder |
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| Affiliation: | 1. UFZ – Helmholtz Centre for Environmental Research, Department of Environmental Immunology, Leipzig, Germany;2. UFZ – Helmholtz Centre for Environmental Research, Core Facility Studies, Leipzig, Germany;3. Helmholtz Centre Munich - German Research Centre for Environmental Health, Institute of Epidemiology I, Neuherberg, Germany;4. IUF- Institut für Umweltmedizinische Forschung, University of Düsseldorf, Germany;5. Marien-Hospital Wesel, Department of Paediatrics, Wesel, Germany;6. Medical Practice for Paediatrics, Bad Honnef, Germany;7. Hospital St. Georg gGmbH Leipzig, Children''s Hospital, Leipzig, Germany;8. University of Leipzig, Dept. of Pediatrics, Leipzig, Germany;9. University of Leipzig, Faculty of Medicine, Environmental Hygiene and Environmental Medicine, Leipzig, Germany |
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| Abstract: | ![]()
ObjectiveObstructive respiratory diseases, mainly the chronic obstructive pulmonary disease (COPD) and asthma, are associated with functional polymorphisms of xenobiotic-metabolizing enzymes (XMEs). To date, association for obstructive bronchitis has not been described.Material/MethodsIn this study, we investigated the genotypes from 26 functional polymorphisms of 20 XMEs in children (n, 1028) at the age of 6 years from the German prospective birth cohort study (LISAplus) and analyzed the associations between genotypes and obstructive bronchitis.ResultsFor the first time, we found noteworthy gene–disease associations for the functional PON1 M55L and EPHX1 H139R polymorphisms and gene–environment associations for the functional COMT V158M and NQO1 P187S polymorphisms after stratification for maternal active smoking behaviour during pregnancy. The noteworthy associations were substantiated by the biological findings that all the risk genotypes belong to genes involved in oxidative stress and code for proteins with a fast enzymatic activity or concomitantly appear in common estrogene-metabolizing pathway (COMT, NQO1).ConclusionThe oxidative stress has to be taken into account in mechanism of the obstructive bronchitis in early childhood. The risk genotypes may serve as risk factors for respiratory obstruction rather than for signs of COPD or asthma. |
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