阈下微脉冲激光在糖尿病黄斑水肿中作用机制的研究进展

阈下微脉冲激光是近年来应用于眼科的一种以长间歇为特征的激光模式，可以在达到有效治疗效应的同时将其对组织的损伤降到最小，目前已应用于糖尿病黄斑水肿（DME）的治疗。早期研究认为，阈下微脉冲激光选择性地作用于视网膜色素上皮细胞，通过调节炎性生物标志物、生长因子、热休克蛋白等物质的表达达到减轻黄斑水肿的目的。近年来随着研究进...

Research advances in the mechanism of subthreshold micropulse laser in diabetic macular edema

In recent years,the subthreshold micropulse laser is a kind of laser mode which is characterized by long intermittence.It achieves effective therapeutic effect while minimizes the damage to tissues.At present,it has been used to treat diabetic macular edema.Early studies suggested that the laser selectively acts on retinal pigment epithelial cells to reduce macular edema by regulating the expression of inflammatory biomarkers,growth factors,heat shock proteins and other substances.In recent years,with the development of research,more and more emphasis has been placed on the role of retinal glial cells.Muller cells are also considered as one of the target cells affected by micropulse laser,but there is no evidence of direct or indirect effects of micropulse laser on Muller cells.In the near future,it is expected that we will have more clinical evidence to confirm the target cells of the micropulse laser,which may be further confirmed by in vitro experiments through Muller cells or Muller cells co-cultured with retina pigment epithelium cells,so as to make a more detailed statement on the mechanism of it.