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| 狭基线纹香茶菜的化学成分 | |
| 引用本文： | 张龙,周光雄,李茜,戴毅,叶文才,姚新生.狭基线纹香茶菜的化学成分[J].沈阳药科大学学报,2006,23(12):768-770,787. |
| 作者姓名： | 张龙 周光雄 李茜 戴毅 叶文才 姚新生 |
| 作者单位： | 1. 沈阳药科大学,中药学院,辽宁,沈阳,110016 2. 暨南大学,中药及天然药物研究所,广东,广州,510632 3. 中国药科大学,中药学院,江苏,南京,210009 |
| 基金项目： | 广州市中药现代化研究重大项目 |
| 摘 要： | 目的对唇形科香茶菜属植物狭基线纹香茶菜(Isodon lophanthoides(Buch.Ham.ex D.Don)Haravar.gerandianus(Benth.)Hara)即中药溪黄草的化学成分进行研究。方法体积分数为95%乙醇提取物的水混悬液经环己烷、乙酸乙酯、正丁醇分步萃取,再对乙酸乙酯层运用硅胶、D101大孔树脂S、ephadex LH 20、ODS等柱层析手段并配合HPLC进行分离、纯化;通过化学方法及波谱分析鉴定其结构。结果分离得到并鉴定了6个化合物:既6去羟基迷迭香酸甲酯(methyl 6 dehy-droxyl rosmarinate,1)、迷迭香酸甲酯(methyl rosmarinate,2)、咖啡酸(caffeic acid,3)、6,7二羟基香豆素(6,7 dihydroxycoumarin,4)、槲皮素(quercetin,5)、蓟黄素(cirsimaritin,6)。结论化合物1为新天然产物,化合物4为首次从该属中分离得到,化合物3、6为首次从该植物中分离得到。 |
| 关 键 词： | 狭基线纹香茶菜 6-去羟基迷迭香酸甲酯 迷迭香酸甲酯 6 7-二羟基香豆素 蓟黄素 |
| 文章编号： | 1006-2858（2006）12-0768-03 |
| 收稿时间： | 2005-12-21 |
| 修稿时间： | 2005-12-21 |
Chemical constituents of Isodon lophanthoides (Buch.- Ham. ex D. Don) Hara var. gerandianus (Benth.) Hara |
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| ZHANG Long,ZHOU Guang-xiong,LI Qian,DAI Yi,YE Wen-cai,YAO Xin-sheng.Chemical constituents of Isodon lophanthoides (Buch.- Ham. ex D. Don) Hara var. gerandianus (Benth.) Hara[J].Journal of Shenyang Pharmaceutical University,2006,23(12):768-770,787. | |
| Authors: | ZHANG Long ZHOU Guang-xiong LI Qian DAI Yi YE Wen-cai YAO Xin-sheng |
| Abstract: | Objective To isolate and identify the constituents of Isodon lophanthoides(Buch.-Ham.ex D.Don)Hara var.gerandianus(Benth.)Hara.Methods Various chromatographic techniques,spectral methods as well as physical and chemical means were used to isolate and identify constituents from I.Lophanthoides(Buch.-Ham.ex D.Don)Hara var.gerandianus(Benth.)Hara.Results Six compounds were obtained and determined as methyl-6dehydroxyl rosmarinate(1),methyl rosmarinate(2),caffeic acid(3),6,7-dihydroxycoumarin(4),quercetin(5)and cirsimaritin(6).Conclusions Among them,compound 1 is a new natural product;compound 4 is isolated from the genus Isodon for the first time,compounds 2 and 6 are isolated from this plant for the first time. |
| Keywords: | I lophanthoides var gerandianus methyl-6-dehydroxyl rosmarinate methyl rosmarinate 6 7-dihydroxycoumarin cirsimaritin |
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