低浓度青石棉污染区间皮瘤的回顾性队列研究

目的 探明云南省大姚县间皮瘤高发的原因，方法 用回顾性队列研究的方法对暴露组和对照组人群的人口学特征，青石棉暴露史，吸烟，被动吸烟，饮茶和家庭肿瘤史的暴露情况及其与间皮瘤的发病关系进行研究。用死亡人群亚队列研究0.015f/cm^3浓度青石棉暴露水平下潜伏期与间皮瘤发病的关系。结果 吸烟，被动吸烟，饮茶，家族肿瘤史与间皮瘤发病无关，低浓度（0.015f/cm^3)青石棉接触与间皮瘤发病有关。结论 暴露组间皮瘤高发的原因在于当地人群暴露于0.015f/cm^3浓度青石棉水平并经历一个较长的潜伏期（下限为29-33年）。

A Retrospective Study of Melignant Mesothelioma in DaYao county Polluted by Low Level Crocidolite

Objective To prove up the cause of high incidence of malignant mesothelioma in population of Da Yao county in Yunnan province. Methods A retrospective cohort study is implemented to collect subjects of exposured population and controlled population. The connection between incidence of maligmant mesothelioma and exposure to smoking, environmental tobacco smoking, familial history of neoplasms and consumption of tea are analyzed. Three subcohorts sourced from dead subjects are set up to analyze the connection between latency and incidence of malignant mesothelioma on the crocidolite level of 0.015f/cm 3. Results Exposure to smoking, environmental tobacco smoking, familial history of neoplasms and consumption of tea are not dangerous factors of malignant mesothelioma. The relative ratio of malignant mesothelioma has a linear increase trend with the increasing length of latency. Conclusions Exposure to environmental low level crocidolite (0.015f/cm 3) was the cause of high malignant mesothelioma in population of Da Yao county.