HIV-1基因亚型研究进展

HIV的典型遗传特征之一是高度的遗传多样性,这一特征为艾滋病患者的抗病毒治疗和HIV疫苗的研制带来了困难,然而也为研究人群中病毒的传播和进化提供了有利条件.根据HIV基因序列和氨基酸序列的特征,HIV-1可分为多种亚型.对HIV-1基因亚型的分析,可敏感地提示HIV的流行信息,及早发现新的HIV亚型毒株的传播,预测HI流行趋势,为艾滋病诊断试剂的更新换代、HIV疫苗的研制提供依据,还可用于估计疾病进展及抗病毒药物治疗的敏感性与耐药性,在预防和控制艾滋病方面发挥重要作用.

Research advances on HIV-1 genetic subtype

One of the typical genetic characteristics of HIV is its high genetic diversity, which brings difficulties to anfiretroviral therapy for the AIDS patients and the development of HIV-1 vaccine. However, it also provides favorable conditions for studying the spread and evolution of the virus. HIV-1 is divided into a variety of subtypes according to the gene sequence and amino acid sequence. Based on the analysis of HIV-1 gene subtype, firstly, the HIV epidemic informarion will be shown sensitively and the successor of a new HIV-1 subtype can be early detected, and the epidemic trends of HIV can be forecast; secondly, meaningful data can be provided for the replacement of diagnostic reagents and the development of HIV-1 vaccine; thirdly, disease progression of AIDS and sensitivity and resistance of antiretroviral therapy can be estimated. After all,HIV-1 subtype plays an important role in the prevention and control of AIDS.