依那普利联用硝苯地平缓释片治疗2型糖尿病合并高血压的疗效观察

目的观察依那普利联合硝苯地平治疗2型糖尿病合并高血压患者的疗效。方法选取我院内分泌科2008年8月至2011年8月间治疗的70例2型糖尿病合并高血压的患者为研究对象。随机将这些患者分两组,对照组35例给予口服依那普利治疗;实验组35例在对照组治疗基础上加用硝苯地平缓释片。观察两组患者在治疗前后血压、血糖的控制及血清肌酐、尿素氮、血钾及24 h尿微量蛋白方面的情况。结果实验组治疗有效率高达100%,而对照组有效率为85.71%,提示实验组治疗效果明显好于对照组(P<0.05);实验组血糖控制、血清肌酐、尿素氮及24 h尿微量蛋白定量的改善情况明显优于对照组(P<0.05),但是在血钾的控制上两组差异无统计学意义(P>0.05)。结论使用依那普利联合硝苯地平治疗2型糖尿病合并高血压可有效控制患者的血糖和血压,并降低血清肌酐、尿素氮及24 h尿微量蛋白的情况,应广泛推荐临床使用。

Clinical efficacy of Enalapril combined with Nifedipine in the treatment of type 2 diabetic patients with hypertension

Objective To observe the efficacy of Enalapril combined with Nifedipine in the treatment of patients with type 2 diabetic complicated by hypertension.Methods Seventy patients with type 2 diabetic complicated by hypertension in the Department of Endocrinology in our hospital from August 2008 to August 2011 were selected for this study.The patients were divided into two groups: the control group(35 cases) received oral enalapril,and the study group(35 cases) was treated with nifedipine sustained-release tablets on the basis of the control group.The blood pressure,blood glucose control,serum creatinine,urea nitrogen,serum potassium and 24-hour urine protein were observed before and after treatment.Results The effective rate was 100% in the study group,significantly higher than 85.71% in the control group(P<0.05).The improvements in blood glucose control,serum creatinine,urea nitrogen and 24-hour urine protein were significantly better than those in the control group(P<0.05).The two groups showed no statistically significant difference on the control of serum potassium(P>0.05).Conclusion For patients with type 2 diabetic complicated by hypertension,Enalapril combined with Nifedipine can effectively control the blood glucose and blood pressure,reduce serum creatinine,urea nitrogen,24-hour urine protein,which is worthy to be widely recommended in clinical pracitce.