| 抗核抗体、免疫球蛋白及补体联合检测对狼疮性肾炎的诊断意义 |
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| 引用本文： | 郭欣,徐兆珍,李晓光,王丽艳,于永光. 抗核抗体、免疫球蛋白及补体联合检测对狼疮性肾炎的诊断意义[J]. 国际检验医学杂志, 2011, 32(14): 1565-1566,1568. DOI: 10.3969/j.issn.1673-4130.2011.14.016 |
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| 作者姓名： | 郭欣 徐兆珍 李晓光 王丽艳 于永光 |
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| 作者单位： | 哈尔滨医科大学附属第一医院检验科,150001 |
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| 摘 要： | 目的探讨抗核抗体(ANA)、免疫球蛋白和补体检测对狼疮性肾炎(LN)和不伴肾炎的系统性红斑狼疮(SLE)的诊断意义。方法对406例SLE患者和120例健康体检者采用间接免疫荧光法测定ANA,应用散射比浊法测定补体(C3、C4)及免疫球蛋白(IgG、IgA、IgM、IgE)。结果 406例SLE患者中,ANA阳性率94.49%,与对照组比较,差异有统计学意义(P<0.01)。SLE患者LN组与非LN组ANA核型均以核均质型和核颗粒型为主,LN组这2种核型占84.35%,非LN组占72.12%,两者差异有统计学意义(P<0.05);LN组胞浆颗粒型占11.31%,与非LN组的21.93%差异有统计学意义(P<0.05)。LN组与非LN组IgG、IgA、IgM、IgE水平均增高,而C3、C4水平均降低,与对照组比较差异有统计学意义(P<0.05);C3水平在LN组降低更明显,与非LN组比较差异有统计学意义(P=0.001)。结论 ANA、免疫球蛋白和补体的联合检测对提高SLE的临床诊断、预后判断、疗效观察等方面意义重大。
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| 关 键 词： | 红斑狼疮,系统性 狼疮肾炎 抗体,抗核 补体系统蛋白质类 免疫球蛋白类 |
Diagnostic significance of combined detection of antinuclear antibody,immunoglobulin and complement for lupus nephritis |
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| Guo Xin,Xu Zhaozhen,Li Xiaoguang,Wang Liyan,Yu Yongguang. Diagnostic significance of combined detection of antinuclear antibody,immunoglobulin and complement for lupus nephritis[J]. International Journal of Laboratory Medicine, 2011, 32(14): 1565-1566,1568. DOI: 10.3969/j.issn.1673-4130.2011.14.016 |
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| Authors: | Guo Xin Xu Zhaozhen Li Xiaoguang Wang Liyan Yu Yongguang |
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| Affiliation: | Guo Xin,Xu Zhaozhen,Li Xiaoguang,Wang Liyan,Yu Yongguang(Department of Laboratory Medicine,the First Affiliated Hospital of Harbin Medical University,Harbin 150001,China) |
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| Abstract: | Objective To explore the diagnostic significance of combined detection of antinuclear antibody(ANA),immunoglobulin and complement for systemic lupus erythematosus(SLE)with or without lupus nephritis(LN).Methods ANA was detected by indirect immunity fluorescent method,and complement(C3,C4)and immunoglobulin(IgG,IgA,IgM,IgE) were detected by nephelometry in 406 SLE patients and 120 health controls.Results Among 406 SLE patients,the positive rate of ANA was 94.49%,and there was significant difference with cont... |
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| Keywords: | lupus erythematosus systemic lupus nephritis antibodies antinuclear complemaent system proteins immunoglobulins |
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