大肠癌患者外周血循环肿瘤细胞的检测及临床意义

大肠癌是最常见的癌症之一,尽管转移患者采取化疗和手术联合治疗后生存率已经有所提高,但是长期存活的患者仍然少之又少.循环肿瘤细胞(CTC)检测是最近兴起的技术,其临床意义已被讨论了将近一个多世纪.科技的日新月异使CTC的检测变得更加可行,最近的研究都相似地揭示CTC可以预测结直肠癌转移患者的临床结局.此篇综述将讨论CTC...

The detection and clinical significance of circulating tumor cells in the peripheral blood of patients with colorectai cancer

Colorectal cancer is one of the most common cancer.Despite the survival rate of patients with metastatic disease has been raised due to the combination therapy of chemotherapy and opetation,few longterm survivors exist.The detection of circulating tumor cells (CTC) is an evolving technology whose significance has been discussed for more than a century.The advence of modem technology has allowed for more reliable detection of CTCs,and recent studies have provided compelling evidence that CTCs can predict clinical outcome in metastatic colorectal cancer (mCRC).In this review,we will discuss the evidence for CTC significance,with particular focus on detection methods,novel markers,and clinical outcomes in CRC,and future challenges in testing them as a means to individualize the therapy of mCRC patients.