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Synthesis and anti-inflammatory and analgesic activities of pyridyloxy- and phenoxyalkanoic acid derivatives |
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| Authors: | Kuk Hyun Shin Soon Sung Lim Sang Hoon Jung Jun Ji Eun Bang Lee Dong Chan Kim Kye Jung Shin Dong Jin Kim Sang Woo Park |
| Affiliation: | Natural Products Research Institute, Seoul National University, Korea. Khshin@plaza.snu.ac.kr |
| Abstract: | Synthesis of pyridyloxy-, pyridyloxyphenoxy- and phenoxylphenoxyalkanate derivatives and their anti-inflammatory and analgesic activities were investigated. Analysis of structure-activity relationships showed that in pyridyloxyalkanoic acid derivatives anti-edematous potency was associated with the presence of chlorophenoxypropionic acid moiety and 2-nitrated methyl propionates contributed to the analgesic activity. |
| Keywords: | Pyridyloxyalkanate Pyridyloxyphenoxyalkanate Phenoxylphenoxyalkanate Anti-inflammatory activity Analgesic activity Carrageenin-induced paw edema Acetic acid writhing syndrome Tail clip pressure test |
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