Prospects for Creation of Cardioprotective and Antiarrhythmic Drugs Based on Opioid Receptor Agonists |
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| Authors: | Leonid N Maslov Igor Khaliulin Peter R. Oeltgen Natalia V. Naryzhnaya Jian‐Ming Pei Stephen A. Brown Yury B. Lishmanov James M. Downey |
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| Affiliation: | 1. Research Institute for Cardiology, Tomsk, Russia;2. School of Clinical Sciences, University of Bristol, Bristol, UK;3. VA Medical Center, University of Kentucky, Lexington, KY;4. Department of Physiology, Fourth Military Medical University, Xi'an, P. R. China;5. National Research Tomsk Polytechnic University, Tomsk, Russia;6. University of South Alabama, Mobile, AL |
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| Abstract: | It has now been demonstrated that the μ, δ1, δ2, and κ1 opioid receptor (OR) agonists represent the most promising group of opioids for the creation of drugs enhancing cardiac tolerance to the detrimental effects of ischemia/reperfusion (I/R). Opioids are able to prevent necrosis and apoptosis of cardiomyocytes during I/R and improve cardiac contractility in the reperfusion period. The OR agonists exert an infarct‐reducing effect with prophylactic administration and prevent reperfusion‐induced cardiomyocyte death when ischemic injury of heart has already occurred; that is, opioids can mimic preconditioning and postconditioning phenomena. Furthermore, opioids are also effective in preventing ischemia‐induced arrhythmias. |
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| Keywords: | opioids heart ischemia/reperfusion injury cardioprotection signal transduction |
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