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| FoxO3a转录因子与心血管疾病的研究进展 | |
| 引用本文： | 郑星星,王建刚. FoxO3a转录因子与心血管疾病的研究进展[J]. 心脏杂志, 2014, 26(2): 222-224 |
| 作者姓名： | 郑星星 王建刚 |
| 作者单位： | (中南大学湘雅三医院心血管内科,湖南 长沙 410013) |
| 摘 要： | FoxO3a是Forkhead家族的一个重要成员。随着对FoxO3a在肿瘤进程中异常表达的研究不断深入,发现其可调节血管平滑肌、内皮细胞及心肌细胞在多种病理生理因素作用下的生物学特性改变,在抗氧化应激中也具有重要作用。FoxO3a与心血管疾病及其危险因素相关,现就其在心血管疾病中的作用研究进展作一综述。 |
| 关 键 词： | 转录因子 FoxO3a 心血管疾病 |
| 收稿时间： | 2013-07-14 |
Research progress in FoxO3a and cardiovascular disease |
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| ZHENG Xing-xing,WANG Jian-gang. Research progress in FoxO3a and cardiovascular disease[J]. Chinese Heart Journal, 2014, 26(2): 222-224 | |
| Authors: | ZHENG Xing-xing WANG Jian-gang |
| Affiliation: | ( Department of Cardiology, Third Xiang-ya Hospital, Central South University, Changsha 410013, Hunan, China) |
| Abstract: | Forkhead Fox O （FoxO） 3a, one of the FoxO family members, has been shown to be deregulated in many types of human cancers. Recent studies have shown that in addition to its activity to enhance vascular antioxidant properties, FoxO3a also appears to be necessary in modulating vascular smooth muscle proliferation, endothelial cell development and cardiomyocyte growth in pathological or biological processes. In this article we review the research progress in FoxO3a and cardiovascular disease. |
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