| 祛胰抵方对2型糖尿病大鼠肝脏IRS-2蛋白表达的影响简 |
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| 引用本文： | 马建,刘畅,赵娜,徐洪涛. 祛胰抵方对2型糖尿病大鼠肝脏IRS-2蛋白表达的影响简[J]. 辽宁中医药大学学报, 2014, 0(3): 7-9 |
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| 作者姓名： | 马建 刘畅 赵娜 徐洪涛 |
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| 作者单位： | [1]黑龙江中医药大学附属第一医院,黑龙江哈尔滨150040 [2]黑龙江中医药大学,黑龙江哈尔滨150040 |
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| 基金项目： | 黑龙江省自然科学基金项目（D201072） |
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| 摘 要： | 目的：观察2型糖尿病大鼠血糖、血清胰岛素浓度和胰岛素受体底物-2（insulin receptor substrate 2,IRS-2）的蛋白表达变化及祛胰抵方对其变化的影响。方法：以小剂量链脲佐菌素（30 mg/kg）腹腔注射合并高脂饮食诱导2型糖尿病大鼠模型,给予不同剂量祛胰抵方治疗12周。分别测定其血糖、血清胰岛素浓度、肝脏组织的IRS-2蛋白表达。结果：造模后2型糖尿病大鼠的血糖、血清胰岛素升高,肝脏组织的IRS-2蛋白表达下降;祛胰抵方能降低模型大鼠的血糖和血清胰岛素,并能显著升高肝脏组织IRS-2的蛋白表达。结论：祛胰抵方治疗2型糖尿病可能与其提高肝脏组织IRS-2的蛋白表达从而改善胰岛素信号传导有关。
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| 关 键 词： | 2型糖尿病 祛胰抵方 胰岛素受体底物-2 |
Effect on Quyidi Prescription on Liver IRS-2 Protein Expression of Type 2 Diabetes Mellitus |
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| MA Jian,LIU Chang,ZHAO Na,XU Hongtao. Effect on Quyidi Prescription on Liver IRS-2 Protein Expression of Type 2 Diabetes Mellitus[J]. Journal of Liaoning University of Traditional Chinese Medicine, 2014, 0(3): 7-9 |
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| Authors: | MA Jian LIU Chang ZHAO Na XU Hongtao |
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| Affiliation: | 1.The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin 150040, Heilongjiang, China; 2. Heilongjiang University of Traditional Chinese Medicine, Harbin 150040, Heilongjiang, China ) |
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| Abstract: | Objective ： To investigate blood glucose, insulin and the protein expression of insulin receptor substrate-2 （ IRS-2 ） of type 2 diabetes mellitus （ T2DM ） rats and effects of Quyidi Prescription on these indexes. Methods ： Model rats of T2DM were induced by intraperitoneal injectin of low dose streptozotocin（ 30 mg/kg ） and fed on high fat-diet. Model rats were treated with different doses Quyidi Prescription for twelve weeks. After treatment, all rats were killed and following indexes were measured： blood glucose, insulin, expression of IRS- 2 protein in liver. Resuhs ： After building model, the blood glucose, insulin of T2DM rats were increased, and expression of IRS-2 protein in liver was decreased in T2DM rats. Quyidi Prescription can reduce the blood glucose and insulin and increase the expression of IHS-2 protein in liver of T2DM rats. Conclusion ： The mechanism of Quyidi Prescription treating T2DM may be partly by raising IRS-2 protein expression in liver to improve insulin resistance. |
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| Keywords: | type 2 diabetes mellitus（ T2DM ） Quyidi Prescription insulin receptor substrate-2（ IRS-2） |
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