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| 肝衰竭的免疫发病机制 | |
| 引用本文： | 王晓晶,张小平,宁琴. 肝衰竭的免疫发病机制[J]. 临床肝胆病杂志, 2014, 0(10): 984-991 |
| 作者姓名： | 王晓晶 张小平 宁琴 |
| 作者单位： | 华中科技大学同济医学院附属同济医院 感染科,武汉,430030 |
| 摘 要： | 导致肝衰竭的主要因素包括直接损伤和免疫介导的肝损伤,越来越多的证据显示免疫介导的肝损伤在肝衰竭的发病中起到了重要作用。就免疫介导的肝损伤作一综述,囊括了人和动物的相关基础及临床研究,对天然免疫和获得性免疫,尤其是各种免疫细胞和免疫分子的相互作用以及细胞凋亡相关分子进行了详细讨论。 |
| 关 键 词： | 肝功能衰竭 免疫,天然 免疫,主动 细胞因子类 死亡结构域受体信号接头蛋白质类 |
Immune -mediated liver failure |
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| WANG Xiaojing,ZHANG Xiaoping,NING Qin. Immune -mediated liver failure[J]. Chinese Journal of Clinical Hepatology, 2014, 0(10): 984-991 | |
| Authors: | WANG Xiaojing ZHANG Xiaoping NING Qin |
| Affiliation: | (Department of Infectious Diseases, Tongji Hospital, Huazhong University of Science and Technology Tongji Medical College, Wuhan 430030, China) |
| Abstract: | The primary causative factors of liver failure include direct damage and immune -mediated liver injury.Increasing evidence sug-gests that immune -mediated injury plays a pivotal role in the pathogenesis of liver failure.The new concepts concerning the mechanisms of immune -mediated liver injury in liver failure are reviewed with relevant basic and clinical studies in both humans and animals.The innate and adaptive immunity,particularly the interaction of various immune cells and molecules,as well as apoptosis -related molecules,are dis-cussed in detail. |
| Keywords: | liver failure immunity,natural immunity,active cytokines death domain receptor signaling adaptor proteins |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |