超临界CO2萃取白芷中香豆素类成分工艺研究

目的：优选超临界CO2萃取白芷中香豆素类成分的工艺。方法：以欧前胡素和异欧前胡素的总量得率和纯度为考察指标，采用单因素实验研究夹带剂、萃取温度、萃取压力、药材粒径、CO2流量、萃取时间等参数的影响，优选白芷中香豆素的超临界CO2萃取工艺。结果：优选工艺务件为：以40％的乙醇为夹带剂，夹带剂流量为0．10mL·min^-1，萃取温度为55℃，萃取压力为20MPa，药材粒径为20-80目，CO2流量为2．0L·min^-1，萃取时间为1．5h。该工艺条件下，香豆素的平均得率为0．202％，纯度为18．5％。结论：所得优化工艺稳定可靠。

Research on Supercritical CO2 Extraction Process of Coumarins from Angelica Dahurica

Objective： To optimize the supercritical CO2 extraction process of coumarins from Angelica dahurica. Methods： The optimal extraction process was selected hy single-factor experiments. The influences of modifier, extraction temperature, extraction pressure, powder particle size, CO2 flow rate and extraction time on the yield and purity of coumarins were discussed. Results： The optimal extraction conditions were as follows： modifier 0.01 mL · min^-1 400/0 alcohol, extraction temperature 55℃, extraction pressure 20 MPa, powder particle size 20-80 mesh, CO2 flow rate 2.0 mL · min^-1, and extraction time 1.5 h. Under these conditions, extraction rate of total coumarins could reach 0.202% and purity could reach 18.50/0. Conclusion： The optimized process conditions are stahle and practicahle in manufacture.