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| 复方鳖甲软肝片防治大鼠腺嘌呤性慢性肾衰竭作用的实验研究 | |
| 引用本文： | 赵宗江,魏晨,杨美娟,牛建昭. 复方鳖甲软肝片防治大鼠腺嘌呤性慢性肾衰竭作用的实验研究[J]. 中国中西医结合肾病杂志, 2005, 6(12): 687-690 |
| 作者姓名： | 赵宗江 魏晨 杨美娟 牛建昭 |
| 作者单位： | 北京中医药大学,北京,100029 |
| 基金项目： | 中国科学院资助项目，教育部长江学者和创新团队发展计划，国家中医药管理局科研项目 |
| 摘 要： | 目的:观察复方鳖甲软肝片对大鼠腺嘌呤性慢性肾衰竭的防治作用.方法:将SD大鼠随机分为正常组、假手术组、模型组、尿毒清组、复方鳖甲软肝片小、中、大剂量组.尿毒清组、复方鳖甲软肝片小、中、大剂量组,以200 mg/kg的腺嘌呤及尿毒清组、复方鳖甲软肝片不同剂量灌胃,共4周,在第2周和第4周时留取24 h尿液、称重,第4周处死大鼠,取血、留取肾组织.测定尿、血Ca2 、P3-及Scr、BUN,用SPSS 11.0进行统计学处理.结果:复方鳖甲软肝片组与模型组比较,慢性肾衰竭大鼠的尿、血Ca2 、P3-及Scr、BUN有不同程度的改善.结论:复方鳖甲软肝片对腺嘌呤性大鼠慢性肾衰竭有一定的防治作用. |
| 关 键 词： | 复方鳖甲软肝片 慢性肾衰竭 腺嘌呤 大鼠 |
| 收稿时间： | 2005-07-12 |
| 修稿时间： | 2005-10-19 |
Prevention and treatment of Adenine- induced Chronic Renal Failure in Rats by Fufangbiejiaruangan preparation |
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| ZHAO Zongjiang, WEI Chen, YANG Meijuan, et al). Prevention and treatment of Adenine- induced Chronic Renal Failure in Rats by Fufangbiejiaruangan preparation[J]. Chinese Journal of Integrated Traditional and Western Nephrology, 2005, 6(12): 687-690 | |
| Authors: | ZHAO Zongjiang WEI Chen YANG Meijuan et al) |
| Abstract: | Objective:To study the prevention and treatment of Adenine-induced Chronic Renal Failure in Rats by Fufangbiejiaruangan preparation.Methods:SD rats were divided into seven groups: normal group,sham group,model group,Niaoduqing control group,three groups with different dosing of Fufangbiejiaruanganpia: low,middle,height.The NO.4 to NO.7 group rats treated with adenine was given Niaoduqing and three different dosing of Fufangbiejiaruanganpian by gavage for 4 weeks.24 hours urine was collected.Rats were killed at 4 weeks and serum calcium,phosphorus,creatinine,blood urea nitrogen were measured.Results:Serum calcium,phosphorus,creatinine,BUN,were improved by Fufangbiejiaruangan preparation.Conclusion:Fufangbiejiaruangan preparation is protective for adenine-induced chronic renal failure in rats. |
| Keywords: | Fufangbiejiamangan preparatioin Adenine Chronic Renal Failure Rat |
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