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| 聚甲基丙烯酸甲酯/聚甲基丙烯酸-2-羟乙酯复合微球的合成及药物吸放性能 | |
| 引用本文： | 张震乾,包永忠,黄志明,翁志学. 聚甲基丙烯酸甲酯/聚甲基丙烯酸-2-羟乙酯复合微球的合成及药物吸放性能[J]. 医学教育探索, 2005, 0(4): 582-585 |
| 作者姓名： | 张震乾 包永忠 黄志明 翁志学 |
| 作者单位： | 浙江大学聚合反应工程国家重点实验室,浙江杭州310027 |
| 摘 要： | 采用在甲基丙烯酸甲酯（MMA）悬浮聚合过程中滴加甲基丙烯酸-2-羟乙酯（HEMA）乳液聚合组分的悬浮-乳液耦合聚合方法，制备了大粒径聚甲基丙烯酸甲酯／聚甲基丙烯酸-2-羟乙酯（PMMA／PHEMA）复合微球。PMMA／PHEMA复合微球表面以HEMA乳液聚合物为主，且具有微孔结构。PMMA／PHEMA复合微球在水和苄醇中的平衡溶胀率大于PMMA微球。PMMA／PHEMA复合微球48h异丁苯丙酸负载百分比为35．6％，PMMA为27．6％。在磷酸盐缓冲液中释放时间达到360h，释放量占负载总量的82％；而PMMA微球的释放时间为216h，释放量仅占负载总量的60％。 |
| 关 键 词： | 甲基丙烯酸甲酯 甲基丙烯酸-2-羟乙酯 复合微球 药物吸放 |
| 修稿时间： | 2005-04-25 |
Synthesis, Drug Absoprtion and Release Properties of Poly(methyl methacrylate)/ Poly( 2-hydroxyethyl methacrylate) Composite Microspheres |
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| ZHANG Zhen-qian,BAO Yong-zhong,HUANG Zhi-ming,WENG Zhi-xue. Synthesis, Drug Absoprtion and Release Properties of Poly(methyl methacrylate)/ Poly( 2-hydroxyethyl methacrylate) Composite Microspheres[J]. Researches in Medical Education, 2005, 0(4): 582-585 | |
| Authors: | ZHANG Zhen-qian BAO Yong-zhong HUANG Zhi-ming WENG Zhi-xue |
| Abstract: | Suspension-emulsion combined polymerization(SECP) process,in which 2-hydroxyethyl methacrylate(HEMA) emulsion polymerization constituents(EPC) were drop-wisely added to methyl methacrylate(MMA) suspension polymerization system,was applied to prepare PMMA/ |
| Keywords: | methyl methacrylate hydroxyethyl methacrylate composite microshpere drug absorption and release |
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