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Correlation of Glut-1 glucose transporter expression with [18F]FDG uptake in non-small cell lung cancer |
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| Authors: | Kotaro Higashi Yoshimichi Ueda Aya Sakurai Xiao MingWang Linfeng Xu Manabu Murakami Hiroyasu Seki Manabu Oguchi Suzuka Taki Yoshihiro Nambu Hisao Tonami Shogo Katsuda Itaru Yamamoto |
| Affiliation: | Department of Radiology, Kanazawa Medical University, Ishikawa, Japan, Department of Pathology, Kanazawa Medical University, Ishikawa, Japan, Medical Research Institute, Kanazawa Medical University, Ishikawa, Japan, Department of Radiology, Kanazawa Cardiovascular Hospital, Ishikawa, Japan, Department of Internal Medicine, Division of Respiratory Disease, Kanazawa Medical University, Ishikawa, Japan, |
| Abstract: | Positron emission tomography (PET) with [18F]2-fluoro-2-deoxy-D-glucose (FDG) may show negative results for bronchioloalveolar lung carcinoma. We investigated the correlation of Glut-1 glucose transporter expression with [18F]FDG uptake in non-small cell lung cancer. Thirty-two patients with 34 non-small cell lung cancers (7 bronchioloalveolar carcinomas, 23 non-bronchioloalveolar adenocarcinomas, 3 squamous cell carcinomas, and 1 adenosquamous cell carcinoma) were studied. Final diagnoses were established by histology (via thoracotomy) in all patients. [18F]FDG PET was performed 40 min after i.v. injection of 185 MBq [18F]FDG. For semi-quantitative analysis of [18F]FDG uptake, standardized uptake values (SUVs) were calculated. Glut-1 expression was studied in terms of the immunohistochemistry of paraffin sections using anti-Glut-1 antibody to determine the intensity (0-3) of Glut-1 immunoreactivity and percentage of the Glut-1-positive area. Of seven bronchioloalveolar carcinomas, six (85.7%) were negative for the expression of Glut-1, while only one (4.3%) of 23 non-bronchioloalveolar adenocarcinomas was negative (P<0.0001). The percentages of Glut-1-positive area, as well as the SUVs, were significantly lower in bronchioloalveolar carcinomas (n=7) (2.86%lj.56% and 1.25ǂ.75, respectively) than in non-bronchioloalveolar adenocarcinomas (n=23) (54.83%ᆭ.64%, P<0.0001, and 3.94ǃ.93, P=0.001, respectively). The degree of cell differentiation correlated with the percentage of Glut-1-positive area and SUVs in adenocarcinoma of the lung. Correlations between SUVs and the intensity of Glut-1 immunoreactivity were also significant (intensities 0 and 1, n=11, SUV 1.47ǂ.63; intensities 2 and 3, n=23, SUV 4.78DŽ.13; P<0.0001). The percentage of Glut-1-positive area correlated significantly with SUVs (n=34, r=0.658, P<0.01). Overexpression of Glut-1 correlated with high [18F]FDG uptake. These findings suggest that Glut-1 expression is related to [18F]FDG uptake in non-small cell lung cancer. Glut-1 expression, as well as [18F]FDG uptake, correlated with the degree of cell differentiation in adenocarcinomas, and both Glut-1 expression and [18F]FDG uptake were significantly lower in bronchioloalveolar carcinomas than in non-bronchioloalveolar carcinomas. |
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