血尿酸水平与2型糖尿病肾病的相关性研究

目的:探讨血尿酸水平与2型糖尿病肾病的相关性。方法:180例2型糖尿病肾病患者根据血尿酸水平分为高尿酸血症组(98例)和正常尿酸组(82例),检测两组患者血糖、糖化血红蛋白、血肌酐、尿素氮及尿微量白蛋白排泄率水平;并将98例高尿酸血症组患者随机平均分为观察组和对照组,其中对照组给予控制血糖等常规治疗,观察组在常规治疗的基础上加用别嘌醇降尿酸治疗,比较治疗2周后两组患者血尿酸及上述指标的变化。结果:高尿酸血症组患者血糖、糖化血红蛋白、血肌酐、尿素氮及尿微量白蛋白排泄率水平均高于正常尿酸组,差异均有统计学意义(P<0.05);治疗2周后,观察组患者血尿酸、血糖、糖化血红蛋白、血肌酐、尿素氮及尿微量白蛋白排泄率水平均低于对照组,差异均有统计学意义(P<0.05)。结论:2型糖尿病肾病患者高尿酸血症与胰岛素抵抗、肾脏损害密切相关。

The research on the relationship between uric acid and type 2 diabetic nephropathy

Objective To explore the relationship between uric acid（ UA）and type 2 diabetic nephropathy. Method 180 patients with type 2 diabetic nephropathy were divided into hyperuricemia group and normal uric acid group including 98 and 82 patients respectively ac-cording to UA. The levels of Glu、HbA1c、Cr、BUN and UAER were measured in each group. Additionally,98 patients in hyperuricemia group were randomly divided into observation group and control group. patients in control group were treated by routine methods including glycemic control. Moreover,allopurinol was used in the treatment of hyperuricemia in observation group. The levels of UA and aforemen-tioned indicators of patients were compared between observation group and control group after 2 weeks of therapy. Results The levels of Glu、HbA1c、Cr、BUN and UAER in hyperuricemia group were significantly higher than normal uric acid group（P〈0. 05）. In addition,the levels of UA and aforementioned indicators in observation group were significantly lower compared to control group（ P〈0. 05）. Conclusion Hyperuricemia of patients with type 2 diabetic nephropathy is closely associated with insulin resistance and renal injury.