| 环孢素A对链脲菌素诱导糖尿病大鼠心脏MMP-2和MMP-9表达的影响 |
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| 引用本文： | 崔瑾,李德强,邱明才,张鹏,张鑫,张金时.环孢素A对链脲菌素诱导糖尿病大鼠心脏MMP-2和MMP-9表达的影响[J].中华内分泌代谢杂志,2010,26(3). |
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| 作者姓名： | 崔瑾 李德强 邱明才 张鹏 张鑫 张金时 |
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| 作者单位： | 天津医科大学总医院内分泌科,300052 |
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| 基金项目： | 天津市科技发展基金，天津市卫生局科技基金 |
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| 摘 要： | 观察环孢素A对糖尿病大鼠心肌基质金属蛋白酶(MMP)表达的影响.发现糖尿病大鼠心肌MMP-2、MMP-9 mRNA和蛋白表达均明显上调(P＜0.05或P＜0.01),环孢素A可下调上述异常表达(P＜0.05或P＜0.01).提示环孢素A可能具有减轻糖尿病心肌细胞损伤的作用.
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| 关 键 词： | 糖尿病 糖尿病心肌病 基质金属蛋白酶 环孢素A |
Effects of cyclosporine A on the expressions of MMP-2 and MMP-9 in the heart of streptozocin-induced diabetic rats |
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| CUI Jin,LI De-qiang,QIU Ming-cai,ZHANG Peng,ZHANG Xin,ZHANG Jin-shi.Effects of cyclosporine A on the expressions of MMP-2 and MMP-9 in the heart of streptozocin-induced diabetic rats[J].Chinese Journal of Endocrinology and Metabolism,2010,26(3). |
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| Authors: | CUI Jin LI De-qiang QIU Ming-cai ZHANG Peng ZHANG Xin ZHANG Jin-shi |
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| Abstract: | The effects of cyclosporine A on matrix metalloproteinases(MMP)-2 and-9 expressions in the cardiac muscle of streptozocin-induced diabetic rats were investigated.The expressions of MMP-2 and MMP-9 mRNA and proteins in the cardiac muscle of diabetic rats were significantly upregulated,which could be decreased by cyclosporine A(P＜0.05 or P＜0.01).The results suggest that cyclosporine A may effectively ameliorate the injuries of diabetic cardiomyopathy. |
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| Keywords: | Diabetes mellitus Diabetic cardiomyopathy Matrix metalloproteinases Cyclosporine A |
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