| 两种检测方法测定抗甲状腺球蛋白抗体和抗甲状腺过氧化物酶抗体结果的比较 |
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| 引用本文： | 张明,王喜青,汪静. 两种检测方法测定抗甲状腺球蛋白抗体和抗甲状腺过氧化物酶抗体结果的比较[J]. 标记免疫分析与临床, 2014, 21(6): 722-725 |
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| 作者姓名： | 张明 王喜青 汪静 |
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| 作者单位： | 西京医院核医学科,陕西西安,710032;西京医院核医学科,陕西西安,710032;西京医院核医学科,陕西西安,710032 |
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| 摘 要： | 目的 应用化学发光免疫分析法（CLIA）和放射免疫分析法（RIA）分别测定血清抗甲状腺球蛋白抗体（抗TgAb）和抗甲状腺过氧化物酶抗体（抗TPOAb）.方法 采用CLIA法和RIA法测定304例不同类型甲状腺疾病患者和38名健康对照者血清抗TgAb和抗TPOAb水平.结果 CLIA法测定血清抗TgAb和抗TPOAb水平与RIA法测定的结果具有良好的一致性.结论 CLIA法测定血清抗TgAb和抗TPOAb可以用来替代RIA法.
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| 关 键 词： | 化学发光免疫分析法 放射免疫分析法 抗甲状腺球蛋白抗体 抗甲状腺过氧化物酶抗体血清 |
Comparison of Chemiluminescence Immunoassay and Radioimmunoassay for the Detection of Serum Anti-thyroglobulin Antibodies and Anti-thyroid Peroxidase Antibodies |
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| ZHANG Ming,WANG Xi-qing,WANG Jing. Comparison of Chemiluminescence Immunoassay and Radioimmunoassay for the Detection of Serum Anti-thyroglobulin Antibodies and Anti-thyroid Peroxidase Antibodies[J]. Labeled Immunoassays and Clinical Medicine, 2014, 21(6): 722-725 |
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| Authors: | ZHANG Ming WANG Xi-qing WANG Jing |
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| Affiliation: | ( Department of Nuclear Medicine, Xijing Hospital, Fourth Military Medical University, Xian 710032, China) |
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| Abstract: | Objective To compare the detection results between chemiluminescence immunoassay （CLIA） and radioimmunoassay（RIA） for serum anti-thyroglobulin antibody （anti-TgAb） and anti-thyroid peroxidase antibodies （anti-TPOAb）. Methods The serum levels of anti-TgAb and anti-TPOAb in 304 patients with different types of thyroid disease and 38 healthy control were detected by using Maglumi Plus 2000 automated CLIA and RIA. Results The serum levels of anti-TgAb and anti-TPOAb in patients and control group tested by CLIA and RIA had no statistically significant differences. Conclusion The anti-TgAb and anti-TPOAb assay by CLIA could be replaced by RIA. |
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| Keywords: | Chemiluminescence immunoassay Radioimmunoassay Anti-thyroglobulin antibodies Anti-thyroid peroxidase antibodies serum |
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