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| 抗肿瘤药物研究Ⅰ:去甲斑蝥素氨基酸衍生物的合成与抗癌活性 | |
| 引用本文： | 田少雷,赵树纬,朱爱堂,方茵,李克庆. 抗肿瘤药物研究Ⅰ:去甲斑蝥素氨基酸衍生物的合成与抗癌活性[J]. 药学学报, 1993, 28(11): 870-875 |
| 作者姓名： | 田少雷 赵树纬 朱爱堂 方茵 李克庆 |
| 作者单位： | 中国医药研究开发中心，中国医药研究开发中心，北京医科大学药化专业，中国医药研究开发中心，中国医药研究开发中心 北京 102206，北京 102206，86级实习生，北京 102206，北京 102206 |
| 摘 要： | In order to search for new compounds with higher anti-cancer activities and lower toxicities, 19 amino acid derivatives of norcantharidin, of which 16 are unknown compounds, were designed and synthesized. Preliminary screening results revealed that 2-(syn-exo-7-oxabicyclo [2. 2. 1] heptane-2, 3-dicarboxylic imido)-N-phenyl glutaramic acid exhibited a fairly apparent inhibitory activity against human-hepatoma cells in vitro (inhibitory rate 39.4% at 0.025 μtmol/ml). |
| 关 键 词： | 去甲斑蝥素 氨基酸衍生物 Bel-4702 抗癌活性 |
| 收稿时间： | 1992-11-21 |
STUDIES ON ANTI-TUMER AGENTS Ⅰ:SYNTHESIS AND ANTI-CANCER ACTIVITY OF AMINO ACID DERIVATIVES OF NORCANTHARIDIN |
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| SL Tian,SW Zhao,AT Zhu,Y Fang and KQ Li. STUDIES ON ANTI-TUMER AGENTS Ⅰ:SYNTHESIS AND ANTI-CANCER ACTIVITY OF AMINO ACID DERIVATIVES OF NORCANTHARIDIN[J]. Acta pharmaceutica Sinica, 1993, 28(11): 870-875 | |
| Authors: | SL Tian SW Zhao AT Zhu Y Fang KQ Li |
| Abstract: | In order to search for new compounds with higher anti-cancer activities and lower toxicities, 19 amino acid derivatives of norcantharidin, of which 16 are unknown compounds, were designed and synthesized. Preliminary screening results revealed that 2-(syn-exo-7-oxabicyclo [2. 2. 1] heptane-2, 3-dicarboxylic imido)-N-phenyl glutaramic acid exhibited a fairly apparent inhibitory activity against human-hepatoma cells in vitro (inhibitory rate 39.4% at 0.025 μtmol/ml). |
| Keywords: | Norcantharidin Amino acid derivatives Bel-4702 Anticancer activity |
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