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Clinical response and tolerability to and safety of saquinavir with low-dose ritonavir in human immunodeficiency virus type 1-infected mothers and their infants |
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| Authors: | Zorrilla Carmen D Van Dyke Russell Bardeguez Arlene Acosta Edward P Smith Betsy Hughes Michael D Huang Sharon Watts D Heather Heckman Barbara Jiménez Eleanor McSherry George Mofenson Lynne |
| Affiliation: | Obstetrics and Gynecology Department, UPR School of Medicine, P.O. Box 365067, San Juan, Puerto Rico. czorrilla@rcm.upr.edu |
| Abstract: | Saquinavir boosted with low-dose ritonavir given with zidovudine and lamivudine was well tolerated by pregnant women and their infants. All mothers had <400 human immunodeficiency virus type 1 RNA copies/ml at delivery. Two had elevated liver transaminases and amylase. Seven infant adverse events were possibly treatment related (anemia, neutropenia, and hyperbilirubinemia). |
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