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1%盐酸布替萘芬软膏治疗体股癣和足癣随机双盲临床试验
引用本文:汪科,王爱平,李春阳,赵广,万喆,余进,李若瑜. 1%盐酸布替萘芬软膏治疗体股癣和足癣随机双盲临床试验[J]. 中国临床药理学杂志, 2004, 20(4): 254-257
作者姓名:汪科  王爱平  李春阳  赵广  万喆  余进  李若瑜
作者单位:1. 北京大学,第一医院,皮肤性病科,北京,100034
2. 山东大学,齐鲁医院,皮肤性病科,山东,济南,250012
3. 中国人民解放军空军总医院,皮肤科,北京,100036
摘    要:目的评价1%盐酸布替萘芬软膏治疗体股癣和足癣的疗效和安全性,并与1%联苯苄唑霜比较。方法 每日外用1次,疗程为体股癣2周、足癣4周,随访2周。结果在停药后2周综合疗效显示,试验组治疗体股癣的痊愈率为81.0%,有效率为98.3%;对照组分别为70.5%和91.8%。试验组治疗足癣的痊愈率为47.6%,有效率为93.6%;对照组分别为50.8%和93.6%。2组间比较均无统计学差异(P>0.05)。结论1%盐酸布替萘芬软膏治疗体股癣和足癣疗效肯定,耐受性好,安全性高。

关 键 词:盐酸布替萘芬软膏  联苯苄唑软膏  体股癣  足癣
文章编号:1001-6821(2004)04-0254-04

Double-blind randomized controlled clinical trial of butenafine hydrochloride 1% cream in the treatment of tinea corporis and cruris and tinea pedis
WANG Ke,WANG Ai-ping,LI Chun-yang,ZHAO Guang,WAN Zhe,YU Jin,LI Ruo-yu. Double-blind randomized controlled clinical trial of butenafine hydrochloride 1% cream in the treatment of tinea corporis and cruris and tinea pedis[J]. The Chinese Journal of Clinical Pharmacology, 2004, 20(4): 254-257
Authors:WANG Ke  WANG Ai-ping  LI Chun-yang  ZHAO Guang  WAN Zhe  YU Jin  LI Ruo-yu
Affiliation:WANG Ke1,WANG Ai-ping1,LI Chun-yang2,ZHAO Guang3,WAN Zhe1,YU Jin1,LI Ruo-yu1
Abstract:Objective To study the efficacy and safety of butenafine hydrochloride1% cream in the treatment of tinea corporis and cruris and tinea pedis. MethodsButenafine hydrochloride 1% cream was compared with bifonazole 1% cream andwas applied once daily for 2 weeks in the treatment of tinea corporis and cruris andfor 4 weeks in the treatment of tinea pedis, both treatment groups had 2 weeks offollow-up observation after the end of treatment. Results Overall cure rates for tineacorporis and cruris at follow-up 2 weeks 81.0% in trial group and 70.5% in controlgroup; overall effective rates were 98.3% versus 91.8%, respectively. Overall curerates for tinea pedis at follow-up 2 weeks 47.6% in trial group and 50.8% in controlgroup; overall effective rates were 93.6% versus93.6%, respectively. The improvedrates between two groups had no statistic differences(P>0.05). Conclusion Butenafinehydrochloride 1% cream is a topical drug with good efficacy, safety and tolerabilityin the treatment of tinea corporis and cruris and tinea pedis.
Keywords:butenafine hydrochloride  bifonazole  tinea corporis and cruris  tineapedis
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