ErbB2 enhances mammary tumorigenesis,oncogene-independent recurrence and metastasis in a model of IGF-IR-mediated mammary tumorigenesis |
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| Authors: | Craig I Campbell James J Petrik Roger A Moorehead |
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| Affiliation: | (1) Dept of Biomedical sciences, University of Guelph, 50 Stone Rd. E, N1G2W1 Guelph, ON, Canada |
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| Abstract: | Background The type I insulin-like growth factor receptor (IGF-IR) and ErbB2 (Her-2) are receptor tyrosine kinases implicated in human breast cancer. Both proteins are currently the subject of targeted therapeutics that are used in the treatment of breast cancer or which are in clinical trials. The focus of this study was to utilize our inducible model of IGF-IR overexpression to explore the interaction of these two potent oncogenes. |
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