上皮型钙黏蛋白在中枢神经系统白血病患者脑脊液中的表达

目的探讨急性白血病（AL）患者脑脊液中可溶性上皮型钙黏蛋白（sE-cad）在中枢神经系统白血病（CNSL）中的发生、发展和疗效判定中的临床意义。方法应用酶联免疫吸附试验（ELISA）检测sE-cad在急性白血病患者脑脊液中的表达。结果脑脊液中sE-cad的浓度（μg/L）：CNSL组显著高于非CNSL组,非CNSL组显著高于对照组,三者之间差异有统计学意义（P〈0.01）;CNSL自身对照：用药前组显著高于用药后（P〈0.01）;在CNSL各阶段中,脑脊液中的sE-cad在初诊时表达水平显著升高,而部分缓解期、完全缓解期逐渐降低。结论急性白血病患者脑脊液中sE-cad的表达与CNSL的发生密切相关;急性白血病患者脑脊液中sE-cad的动态变化是反映AL患者的病情及治疗效果的重要指标,是CNSL诊断、鉴别诊断、判定复发、疗效和预后的监测指标之一。

The clinical significance of soluble E-cadherin in central nervous system leukemia

Objective To study the expression of soluble E-cadherin（SE-cad） in cerebrospinal fluid and its clinical significance in the pathogenesis,disease development and prognosis of central nervous system leukemia（CNSL）.Methods Enzyme-linked immunoabsorbent assay（ELISA） was used to determine the expression of sE-cad in the cerebrospinal fluid of patients with acute leukemia.Results The concentration of sE-cad in cerebrospinal fluid was significantly higher in CNSL patients（0.86 μg/L） than that in non-CNSL patients（0.65 μg/L） or in the control group（0.47 μg/L）（P0.01）.The expression levels of sE-cad decreased significantly with effective treatment in partially or completely released CNSL patients（P0.01）.Conclusion The expression of E-cad in cerebrospinal fluid was closely associated with the disease processing of CNSL.The dynamic changes of the E-cad may be helpful in the diagnosis and evaluation of treatment efficacy of the disease.