急性心肌梗塞患者血浆内皮素的变化

目的；研究急性心肌梗塞（ＡＭＩ）患者血浆内皮素（ＥＴ）的变化。方法ＡＭＩ患者随机分溶栓（１７例）与非溶栓（１４例）两组，溶栓组分为溶栓成功组９例（早期再灌），溶栓未成功组８例（非早期再灌）。测外周血浆ＥＴ值，并于入院后３周左右行彩色多普勒扫描。结果：ＡＭＩ患者入院初血浆ＥＴ浓度明显高于正常组，早期财灌较非再灌高山筻 高及高山箭移且持续时间短，各组ＥＴ峰值性与彩色多普勒测得左室射血分数（ＬＶＥＦ）无

Dynamic changes of plasma endothelin in patients with AMI and their clinical significance

To investigate the change of plasma endothelin(ET) in patients with acute myocardial infarction(AMI). Methods:Of the 31 patients with confirmed AMI, 17 received thrombolytic therapy,14 did not(grouped as non-thrombolysis). The 17 patients receiving thrombolytic therapy were divided into two groups, 9 of them met the criteria for successful thrombolysis(grouped as early reperfusion),whereas 8 did not (grouped as non-early reperfusion). Plasma ET was measured. All patients received Dopple's examination of 3 weeks after admission. Results:Plasma concentration of ir-ET in patients with AMI at the time of admission was significantly increased as compared with that of healthy control group.Comparing early reperfusion group with non-early reperfusion group,the ir-ET peak was higher and forerer, and the time was shorter. No correlation was found between ir-ET peak value and left ventricular ejective fraction(LVEF). Higher Killip classes corresponded with higher ir-ET peak values. Conclusion:ET has some effect on coronary reperfusion.