74例Ⅲ期非小细胞肺癌患者术后放疗、化疗或联合放化疗的疗效比较

目的观察和评价Ⅲ期非小细胞肺癌（non-small cell lung carcinoma，NSCLC）患者术后放疗、化疗和放化疗同步综合治疗的临床疗效及毒副反应。方法将在我院住院治疗的74例Ⅲ期NSCLC患者随机分成：A组（单纯术后放疗）24例、B组（单纯术后化疗）24例、C组（术后放化疗综合治疗）26例，A组采取60Coγ射线或者8MV．X射线常规分割治疗；B组采用以顺铂（cis-diamminedichloro．platinum，DDP）为主的化疗方案；C组采用NP方案联合放射治疗方案，比较三组近期疗效、中位生存时间及毒副反应。结果总有效率A组54．2％，B组62．5％，C组80．8％。结果显示C组明显高于A、B组（P〈0．05）。毒副反应主要为骨髓抑制、消化道反应、放射性肺炎、放射性食管炎，经对症治疗后好转。结论化疗综合治疗Ⅲ期NSCLC可提高有效率，减少远处转移率，从而提高远期生存率。

Curative Effect Observation of 74 NSCLC Patients with Radiation Combined Chemotherapy after Surgery

Objective To observe and evaluate the curative effect and side effects of radiotherapy, chemotherapy and combined modality therapy in the treatment of stage m non-small cell lung cancer, neth- otis 74 patients with non-small cell lung cancer at stage m were randomly divided into A group （ postoperative radiotherapy）, B group （postoperative chemotherapy） and C group （combined modality therapy）. Patients in A group were given 60Coγ/or 8MV-X radial conventional treatment of segmentation; B group were given postoperative chemotherapy with cisplatin （DDP） ; C group were given NP plan combined radiotherapy. Short term curative effect, median survival time and side effects were compared among the above three groups. Results Overall response rate of A, B and C was 54.2%, 62.5% and 80.8%, respectively. As a result, the overall response rate and survival rate of C group were all much higher than that of A, B group. The toxic and side effects were mainly myelosuppression, gastrointestinal reaction, radiation pneumonia and radiation esophagitis. Conclusion Compared with radiotherapy and chemotherapy, concurrent chemo-radiotherapy could greatly im- prove short term curative effects and survival time of patients with non-small cell lung cancer at stage III.