Weight loss improves biomarkers endothelial function and systemic inflammation in obese postmenopausal Saudi women

BackgroundAlthough postmenopausal associated disorders are important public health problems worldwide, to date limited studies evaluated the endothelial function and systemic inflammation response to weight loss in obese postmenopausal women.ObjectiveThis study was done to evaluate the endothelial function and systemic inflammation response to weight loss in obese postmenopausal Saudi women.ResultsThe values of body mass index(BMI), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), C-reactive protein (CRP), inter-cellular adhesion molecule (ICAM-1), vascular cell adhesion molecule (VCAM-1) and plasminogen activator inhibitor-1 activity (PAI-1:Ac) were significantly decreased in group (A), while changes were not significant in group (B). Also, there were significant differences between mean levels of the investigated parameters in group (A) and group (B) after treatment.ConclusionWeight loss ameliorates inflammatory cytokines and markers of endothelial function in obese postmenopausal Saudi women.