急性心肌梗死与纤维蛋白原和血小板膜糖蛋白基因多态性关系

目的探讨急性心肌梗死（AMI）患者B纤维蛋白原（Fg）-455A基因多态性、血小板膜糖蛋白（GP）Ia807T基因多态性与AMI发病的关系。方法应用聚合酶链反应-限制性片段长度多态性（PCR—RFLP）方法检测120例AMI及120例正常人的βFg-455G／A和GP1a807C／T基因型。结果在安徽地区汉族人群中，AMI组βFg-455A等位基因频率显著高于对照组（X^2=5．91，P〈0.05），AMI组GPIa807T等位基因频率显著高于对照组（X^2=7．33，P〈0．01）。结论在安徽汉族人中，BFg-455A与GPIa807T等位基因可能是AMI患者的遗传危险因素。

Association of beta Fibrinogen Gene 455G/A and platelet glycoprotein Ia C807T gene polymorphism with Acute Myocardial Infarction

Objective To investigate the association of beta fibrinogen gene 455G/A and platelet glycoprotein Ia C807T gene polymorphism with acute myocardial infarction （AMI）. Methods β-Fg-455G/A and GP Ia C807T genotypes were detected in 120 patients with AMI and 120 healthy controls by PCR-restriction fragment length polymorphism technique. Results There were significant differences in be- ta Fg-455A and GP Ia 807T allele distributions between AMI and healthy control group. The frequency of beta Fg -455A allele in AMI group were higher than that in control group （X^2 =5.91, P 〈0. 05） , and the frequency of GP Ia-807T allele in AMI group were higher than that in control group （ X^2 = 7.33, P 〈 0. 01 ）. Conclusion The platelet collagen receptor beta Fg -455A and GP Ia 807T allele might be an independent risk factor for the development of AMI in Han population of Anhui province.