| 积雪草总苷对实验性抑郁症大鼠血清皮质酮和单胺类神经递质的影响 |
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| 引用本文： | 陈瑶,韩婷,芮耀诚,殷明,秦路平,郑汉臣. 积雪草总苷对实验性抑郁症大鼠血清皮质酮和单胺类神经递质的影响[J]. 中药材, 2005, 28(6): 492-496 |
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| 作者姓名： | 陈瑶 韩婷 芮耀诚 殷明 秦路平 郑汉臣 |
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| 作者单位： | 1. 上海交通大学药学院,上海,200030
2. 第二军医大学药学院,上海,200433 |
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| 基金项目： | 军队“十五”指令性课题(01L058)，国家自然科学基金(30100242) |
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| 摘 要： | 目的:探讨积雪草总苷抗抑郁症可能的作用机制.方法:采用荧光法检测积雪草总苷对实验性抑郁症大鼠血清皮质酮的影响;HPLC-ECD法检测积雪总苷对大鼠皮质、海马和下丘脑单胺类神经递质含量的影响.结果:积雪草总苷降低抑郁症大鼠的血清皮质酮水平,增加脑内5-HT,NE和DA及其代谢产物的含量.结论:积雪草总苷的抗抑郁活性与改善下丘脑-垂体-肾上腺轴功能和增加胺神经递质的水平有关.
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| 关 键 词： | 积雪草总苷 长期未预知应激刺激 皮质酮 单胺神经递质基金资助:军队" 十五" 指令性课题(01L058) 国家自然科学基金(30100242) |
| 修稿时间： | 2004-12-23 |
Effects of Total Triterpenes of Centella asiatica on the Corticosterone Levels in Serum and Contents of Monoamine in Depression Rat Brain |
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| Chen Yao,HAN Ting,RUI YaoCheng,Yin Ming,Qin Luping,Zheng Hanchen. Effects of Total Triterpenes of Centella asiatica on the Corticosterone Levels in Serum and Contents of Monoamine in Depression Rat Brain[J]. Journal of Chinese medicinal materials, 2005, 28(6): 492-496 |
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| Authors: | Chen Yao HAN Ting RUI YaoCheng Yin Ming Qin Luping Zheng Hanchen |
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| Affiliation: | Pharmacy School, Shanghai Jiao Tong University, Shanghai. |
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| Abstract: | Objective: To investigate the possible effect of antidepressant effect of total triterpentes of Centella asiatica. Methods: The corticosterone levels in serum were measured by fluorescence spectroscopy. The contents of monoamine neurotransmitters and their metabolites in rats cortex, hippocamopus and thalamus were evaluated by using HPLC with electrochemical detector. Results: Significant reduction of the corticosterone level in serum and increase of the contents of 5-HT, NE, DA and their metabolites 5-HIAA, MHPG in rat brain were observed. Conclusion: The antidepressant effect of total triterpenes of Centella asiatica may be involved in ameliorating the function of HPA axis and increasing the contents of monoamine neurotransmitters. |
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| Keywords: | Total triterpenes of Centella asiatica Chronic unpredictable stress Corticosterone Monoamine neurotransmitters |
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