Characteristics of pediatric invasive pneumococcal diseases and the pneumococcal isolates in Suzhou,China before introduction of PCV13 |
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| Institution: | 1. Department of Epidemiology, School of Public Health, Fudan University, Shanghai 200032, China;2. Key Laboratory of Public Health Safety, Ministry of Education, Shanghai, China;3. Collaborative Innovation Center of Social Risks Governance in Health, Shanghai, China;4. Soochow University Affiliated Children’s Hospital, Suzhou, China;1. Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China;2. Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong;3. Laboratory of Data Discovery for Health (D²4H), Hong Kong, China;4. Institute of Environment, Energy and Sustainability, The Chinese University of Hong Kong, Hong Kong, China;5. Department of Non-communicable Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK;6. School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China;7. School of Nursing, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China;8. Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China;9. Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China;10. Department of Social Work and Social Administration, Faculty of Social Sciences, The University of Hong Kong, Hong Kong, China;11. Sau Po Centre on Ageing, The University of Hong Kong, Hong Kong, China;12. Research Department of Policy and Practice, University College London School of Pharmacy, London, UK;13. Centre for Mathematical Modelling of Infectious Diseases, Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK;1. Epidemiology, Worldwide Safety and Regulatory, Pfizer Inc, New York, NY, USA;2. Statistical Research and Consultation Center, Pfizer Inc, New York, NY, USA;3. Biostatistician Consultant, Pittsboro, NC, USA;4. Vaccine Clinical Research and Development, Pfizer Inc, Collegeville, PA, USA;1. National Immunization Program Center, Chinese Center for Disease Control and Prevention, Beijing 10050, PR China;2. National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, PR China;1. Immunobiology Unit, UCL Great Ormond Street Institute of Child Health, London, UK;2. Immunisation Hepatitis and Blood Safety Department, Public Health England, Colindale, London UK;3. Statitstics, Modelling and Economics Department, Public Health England, Colindale, London UK;4. Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK |
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| Abstract: | BackgroundData on characteristics of invasive pneumococcal diseases (IPD) is limited in China. We aimed to understand the clinical features and explore the molecular characteristics of the pneumococcal isolates in China.MethodsSince 2010, we prospectively collected the pneumococcal isolates and the IPD patients’ demographic and clinical information in Suzhou University Affiliated Children’s Hospital (SCH). The antibiotic susceptibility, serotypes, genotypes of Streptococcus pneumoniae strains were identified by E-test, quellung reaction and/or multiplex PCR, and multi-locus sequence typing, respectively.ResultsDuring the period from January 2010 to December 2015, a total of 80 IPD patients were identified. They were diagnosed as meningitis (31.3%), septicemia (27.5%), pneumonia (21.3%) and others (20.0%). About half of them required vancomycin treatment, 42.5% were admitted to ICUs, 36.2% had complications and 6.2% were hospitalized for over 1 year. The most common serotypes of the pneumococcal isolates were serotypes 6B and 14, the coverage of PCV13 was 92.5%, and CC236s and CC199s were the most common clone complexes.ConclusionsPediatric IPD patients had severe clinical symptoms, demanded intensive treatment, suffered poor prognosis and substantial burden. The pneumococcal isolates’ serotype coverage of PCV13 vaccine was high, which leads to implication of PCV vaccine usage among children in China. |
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| Keywords: | Invasive pneumococcal disease Children Suzhou |
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