Kawasaki disease and immunisation: A systematic review |
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| Affiliation: | 1. Monash Children’s Hospital, Clayton, Melbourne, Australia;2. Royal Children’s Hospital, Parkville, Victoria, Australia;3. Italian Medicines Agency (AIFA), Rome, Italy;4. Murdoch Childrens Research Institute, Parkville, Victoria, Australia;5. Department of Paediatrics, Monash University, Clayton, Victoria, Australia;6. The Brighton Collaboration Foundation, Basel, Switzerland;7. Uppsala Monitoring Centre, Uppsala, Sweden;8. Independent Consultant, Bethesda, MD, USA;9. Department of Vaccines Control, National Agency for Medicines and Medical Devices, Tirana, Albania;10. Pharmacovigilance Regional Centre of Lombardy, Italy;11. Children’s Mercy Hospital, Kansas City, MO, USA;12. Ann & Robert H. Lurie Children’s Hospital of Chicago, USA;13. Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada;14. Hospital Nacional de Niños “Dr. Carlos Sáenz Herrera, San José, Costa Rica;15. Independent Consultant Vaccinologist, Wakefield, RI, USA;p. Boston Children’s Hospital, Boston, USA;q. CHU Sainte-Justine, Montreal, Canada;r. Post Graduate Institute of Medical Education and Research (PGIMER)- Chandigarh, India;s. University of Basel Children’s Hospital, Basel, Switzerland;t. Department of Paediatrics, Melbourne University, Parkville, Victoria, Australia |
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| Abstract: | ![]()
BackgroundKawasaki disease is a complex and potentially serious condition. It has been observed in temporal relation to immunisation.MethodsWe conducted a systematic literature review using various reference sources to review the available evidence published in the literature.ResultsWe identified twenty seven publications reporting a temporal association between immunisation and Kawasaki disease. We present a systematic review of data drawn from randomised controlled trials, observational studies, case series and reports, and reviews. Overall there was a lack of standardised case definitions, making data interpretation and comparability challenging.ConclusionsAlthough a temporal relationship between immunisation and Kawasaki disease is suggested, evidence for an increased risk or a causal association is lacking. Implementation of a standardised Kawasaki disease case definition would increase confidence in the findings and add value to future studies of pre- or post-licensure vaccine safety studies. |
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| Keywords: | Kawasaki disease Adverse event Immunisation Guidelines Case definition Systematic review |
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