胱抑素C水平与冠心病的相关性分析

目的:探讨胱抑素C(Cys-C)水平与冠状动脉性心脏病(CHD)的关系及临床意义.方法 :随机选取疑似CHD病人进行选择性冠状动脉造影术,其中164例确诊为CHD(CHD组),另选99例非冠心病为对照组.采集研究对象外周静脉血检测Cys-C水平.并分析不同类型CHD病人Cys-C水平,采用Pearson相关分析显示冠状动脉病变支数、Gensini评分与Cys-C的相关性.结果 :与对照组比较,CHD组Cys-C水平增高(P<0.05).CHD组间比较,不稳定型心绞痛组Cys-C水平高于稳定型心绞痛组(P<0.05),但急性心肌梗死组低于稳定性心绞痛组(P<0.05).Cys-C诊断CHD的ROC曲线下面积为0.711(P<0.05),以1.105 mg/L为Cut-off值,Cys-C诊断CHD的敏感性73.2%,特异性55.6%.Cys-C水平与Gensini评分呈正相关关系关系(r=0.332,P<0.05),与冠状动脉病变支数呈正相关关系(r=0.413,P<0.05).结论 :Cys-C可作为CHD的一项无创预测指标,与冠状动脉病变程度密切相关.

Analysis of the correlation between the serum level of cystatin C and coronary heart disease

Objective:To study the correlation between the serum level of cystatin C(Cys-C)and coronary heart disease(CHD),and its clinical significance. Methods:The suspected CHD patients were detected using selective coronary angiography, and 164 CHD patients and 99 non-CHD patients were divided into the CHD group and control group,respectively. The serum levels of Cys-C in all cases were tested. The correlations between the coronary artery lesion, Gensini score and Cys-C level were analyzed using Pearson correlation analysis. Results:Compared with the control group,the levels of Cys-C in CHD group significantly increased(P<0. 05). Among CHD group,the levels of Cys-C in unstable angina pectoris group were higher than that in stable angina group(P<0. 05),but the levels of Cys-C in acute myocardial infarction group were lower than that in stable angina group(P<0. 05). The area under the ROC curve of CHD diagnosed by Cys-C was 0. 711(P<0. 05). Taken 1. 105 mg/L as the Cut-off value,the sensitivity and specificity of CHD diagnosed by Cys-C were 73. 2% and 55. 6%,respectively. The level of Cys-C was positively related with the Gensini score(r=0. 332,P <0. 05) and the number of coronary artery lesion(r = 0. 413,P <0. 05). Conclusions:Cys-C could be used as a noninvasive predictor of CHD,which is closely related to the degree of coronary artery lesion.