持续静脉泵入乌拉地尔与持续静脉泵入硝普钠治疗高血压合并急性左心力衰竭的疗效比较

目的:探讨持续静脉泵入乌拉地尔与持续静脉泵入硝普钠治疗高血压合并急性左心力衰竭(心衰)的疗效.方法 :选取高血压合并急性左心衰病人112例,按随机数字法分为观察组和对照组,每组56例,2组均在综合治疗基础上,对照组给予持续静脉泵入硝普钠,观察组给予持续静脉泵入乌拉地尔,观察2组的临床疗效和不良反应.结果 :治疗24 h后观察组治疗总有效率为92.9%,高于对照组的71.4%(P<0.05).治疗1 h后2组心率、收缩压和舒张压均较治疗前改善,治疗后观察组收缩压变化的差值较对照组改善(P<0.05),但2组心率、舒张压变化差异均无统计学意义(P>0.05).治疗前2组N-端脑利钠肽水平差异无统计学意义(P>0.05),治疗后2组N-端脑利钠肽水平均较治疗前有所下降,但观察组下降更为明显(P<0.05).对照组不良反应发生率高于观察组(P<0.05).结论 :与硝普钠相比,经静脉泵入乌拉地尔在治疗高血压并发急性左心衰临床疗效好且不良反应少,值得临床推广应用.

Clinical effect comparision of continuous pumping ebrantil with nitroprusside in the treatment of hypertension complicated with acute left heart failure

Objective:To compare the clinical effects of continuous pumping ebrantil with nitroprusside in the treatment of hypertension complicated with acute left heart failure. Methods:One hundred and twelve patients with acute left heart failure complicated with hypertension were divided into the observation group and control group according to the random number method ( 56 cases each group ) . The observation group and control group were treated with ebrantil and nitroprusside by continuous intravenous pumping based on comprehensive treatment, respectively. The clinical effects and adverse reactions in two groups were observed. Results:After 24 h of treatment,the total effective rate in observation group(92. 9%) was significantly higher than that in control group (71. 4%)(P<0. 05). After 1 h of treatment,the heart rate,systolic blood pressure and diastolic blood pressure in two groups were significantly improved(P<0. 05),the difference of systolic blood pressure in observation group was significantly improved compared with control group(P<0. 05),and the differences of changes of the heart rate and diastolic blood pressure between two groups were not statistically significant(P>0. 05). The difference of the level of NT-proBNP between two groups before treatment was not statistically significant(P>0. 05). The levels of NT-proBNP in two groups after treatment decreased compared with before treatment,but the decreasing degree of which was more obvious in observation group(P<0. 05). The incidence rate of adverse reactions in observation group was lower than that in control group(P <0. 05). Conclusions:Compared with nitroprusside,the treatment of hypertension complicated with acute left heart failure with ebrantil has lower adverse reactions and good effects,which is worthy of clinical promotion.